PRELIMINARY PROGRAM

16:00 - 16:30

A-0163 Spermatogonial Stem Cell-based therapies: from innovation to implementation
Ellen Goossens
Belgium

17:00 - 17:20

A-0024 Genetic Architecture of Penile Volume in the General Population
Gunnar P Kordes ¹, Philipp Beeken ¹, Lynn Ogoniak ², Jan Ernsting ^3,4,5 Nils Johannaber ¹, Benjamin Risse ^3,4, Alexander S Busch ^1
1 Department of General Pediatrics, University Hospital Münster, Germany; ² Institute of Medical Informatics, University of Münster, Germany; ³ Institute for Geoinformatics, University of Münster, Germany; ⁴ Faculty of Mathematics and Computer Science, University of Münster, Germany; ⁵ Institute for Translational Psychiatry, University of Münster, Germany

17:20 - 17:40

A-0101 Diffusion-Generated Synthetic Testicular Ultrasound Images for AI Development in Male Infertility Assessment
Daniele Renda Livraghi ^1,2, Giorgia Spaggiari ^1,2,3, Antonio R. M. Granata ^1,3, Carlotta Pozza ⁴, Marta Tenuta ⁴, Andrea M. Isidori ⁴, Manuela Simoni ^1,2, Nicola Morelli ⁵, Kevin Marchesini ⁵, Federico Bolelli ⁵, Costantino Grana ⁵, Daniele Santi ^1,2,3
1 Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, 41126, Modena, Italy; ² Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41126, Modena, Italy; ³ Unit of Andrology and Sexual Medicine of the Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, 41126, Modena, Italy; ⁴ Section of Medical Pathophysiology and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy; ⁵ Enzo Ferrari Department of Engineering, University of Modena and Reggio Emilia, 41125, Modena, Italy

17:40 - 18:00

A-0110 The remodeling of nuclear transport at the mitosis-to-meiosis transition is a crucial determinant for successful spermatogenesis
Joana Martins Almeida ¹, Margot J. Wyrwoll ², Antoni Riera-Escamilla ³, Inês Ferreira ¹, Catarina Lopes ⁴, Laura Quintas ⁵, João Guimarães ⁵, Sabine Kliesch ⁶, Corinna Friedrich ⁷, Nuno Santos ⁴, Donald F. Conrad ³, Joris Veltman ², Frank Tüttelmann ⁷, Paulo Navarro-Costa ^1
1 EvoReproMed Lab, Lisbon School of Medicine, Lisbon, Portugal; ² Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK; ³ Oregon Health & Science University, Oregon, USA; ⁴ Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal; ⁵ ERA Chair iSTARS, Lisbon School of Medicine, Lisbon, Portugal; ⁶ Department of Andrology, Centre of Reproductive Medicine and Andrology, University Hospital Münster, Münster, Germany; ⁷ Institute of Reproductive Genetics, Centre of Medical Genetics, University of Münster, Münster, Germany

08:00 - 08:30

A-0170 Practical interpretation of a WES report in diagnosing male infertility
Frank Tüttelmann
Germany

08:00 - 08:06

A-0275 Assessing gene expression and chromatin accessibility dynamics in the early prepubertal Sertoli cell population of the primate testis
Nadia Y Edelsztein ¹, Stefan Schlatt ², Alexander S Busch ^1
1 Department of General Paediatrics, University of Münster, Münster, Germany; ² Centre for Reproductive Medicine and Andrology, Münster, Germany

08:06 - 08:12

A-0042 Sexual Dysfunction in Male IBD Patients on Advanced Treatments: Insights into a Neglected Dimension of Quality of Life
Marilina Romeo ¹, Cristina Bezzio ^2,3, Walter Vena ^1,2, Giulia Migliorisi ³, Andrea Dall'Oca ^1,2, Roberto Gabbiadini ³, Laura Loy ³, Giuseppe Privitera ^2,3, Antonio Carlo Bossi ¹, Ferdinando D'Amico ⁴, Andrea Sansone ⁵, Alessandro Pizzocaro ^2,6, Alessandro Armuzzi ^2,3, Andrea Gerardo Lania ^2,6
1 Endocrinology and Diabetes Unit, Humanitas Gavazzeni, Bergamo, Italy; ² Department of Biomedical Sciences, Humanitas University, Milan, Italy; ³ IBD Center, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Milan, Italy; ⁴ Department of Gastroenterology, IRCCS Ospedale San Raffaele, Milan, Italy; ⁵ Chair of Endocrinology and Sexual Medicine (ENDOSEX) Department of System Medicine, University of Rome Tor Vergata, Rome, Italy; ⁶ Endocrinology, Diabetology and Medical Andrology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy

08:12 - 08:18

A-0046 Human Sertoli-to-granulosa cell transdifferentiation caused by a somatic DMRT1 mutation evidenced by a testicular granulosa cell tumor case
Sofia Boeg Winge ^1,2, Terje Svingen ³, Niels Erik Skakkebaek ^1,2, Maria Rossing ⁴, Lise Barlebo Ahlborn ⁴, Birgitte Grønkær Toft ^5,6, Lise Aksglaede* ^1,2, Gedske Daugaard* ^7
1 Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Denmark; ² International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet; ³ National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark; ⁴ Department of Genomic Medicine, Copenhagen University Hospital - Rigshospitalet; ⁵ Department of Pathology, Copenhagen University Hospital - Rigshospitalet; ⁶ Department of Clinical Medicine, University of Copenhagen, Denmark ⁷ Department of Oncology, Copenhagen University Hospital - Rigshospitalet; *Shared last authors

08:18 - 08:24

A-0093 Luteinizing hormone (LH) and human choriogonadotropin (hCG) induce ligand-specific steroid secretion profile in the mouse Leydig tumor cell line 1 (mLTC1)
Clara Lazzaretti ¹, Carmela Perri ^1,2, Flaminia Fanelli ³, Valentina Bissi ³, Giada Mercanile ^1,4, Samantha Sperduti ^1,5, Monica Lispi ⁶, Daniele Santi ^1,7, Manuela Simoni ^1,5,7, Livio Casarini ^1,5
1 Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; ² International PhD School in Clinical and Experimental Medicine (CEM) University of Modena and Reggio Emilia, Modena, Italy; ³ Endocrinology research group, Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; ⁴ Department of Dermatology, Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy; ⁵ Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy; ⁶ Global Medical Affairs Fertility, Research and Development, Merck Healthcare KGaA, Darmstadt, Germany; ⁷ Azienda Ospedaliero-Universitaria di Modena, Department of Medical Specialties, Modena, Italy

08:24 - 08:30

A-0148 Slower Pubertal Trajectory Based on Testicular Volume, but Not Tanner Genitalia Staging, Predicts Reproductive Outcomes and Relates with Sperm Epigenetic Markers in Young Adulthood
Vitalik Bezuglov ^1,2*, Anna Ponomareva ¹*, Victoria Shtratnikova ^1,2, Vasily Ashapkin ^1,2, Alexander Suvorov ³, Oleg Sergeyev ^1,2,4
1 Skolkovo Institute of Science and Technology, Moscow, Russia; ² Lomonosov Moscow State University, Moscow, Russia; ³ University of Massachusetts, Amherst, USA; ⁴ Research Centre for Medical Genetics, Moscow, Russia

08:30 - 08:36

A-0057 Impairment of Male Reproductive Function After Isotretinoin Exposure
Fie Bendix ^1,2, Lærke Priskorn ^1,2, Niels Jørgensen ^1,2, Hanne Frederiksen ^1,2, Anne Jørgensen ^1,3, Lina Mørch ⁴, Hans Christian Ring ⁵, Anna Rosenmai ⁶, Terje Svingen ⁶, Anders Juul ^1,2,7, Anders Rehfeld ^1,2
1 The Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Denmark; ² Center for Research in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital, Denmark; ³ Division of Translational Endocrinology, Department of Endocrinology and Internal Medicine, Copenhagen University Hospital, Herlev and Gentofte, Denmark; ⁴ Cancer and Medicine, Danish Cancer Institute - Danish Cancer Society, Copenhagen, Denmark; ⁵ Department of Dermatology, Zealand University Hospital, Roskilde, Denmark; ⁶ National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark; ⁷ Department of Clinical Medicine, University of Copenhagen, Denmark

08:36 - 08:42

A-0069 Stimulation of the Leydig cells androgenic response using LH receptor agonist as a potential therapy for hypogonadism in Klinefelter syndrome
Fariba Saadati, Reinhild Sandhowe-Klaverkamp, Nora Elena Büttner-Wobst, Joachim Wistuba
Institute of Reproductive and Regenerative Biology, Centre of Reproductive Medicine and Andrology, University of Muenster, Muenster, Germany

08:42 - 08:48

A-0100 Can Microlithiasis disrupt Testicular Immune Privilege? Analysis on 1,755 Infertile Men
Civilla Matteo, Tienforti Daniele, Spagnolo Luca, Pisanó Carlo, Cocci Elisa, Barbonetti Arcangelo
Andrology Unit, Hospital S. Salvatore, Department of Medical, Health, Life and Ambiental Sciences, University of L'Aquila, L'Aquila, Italy

08:48 - 08:54

A-0226 Machine learning models may predict the presence of validated pathogenic/ likely pathogenic gene variants in men with non-obstructive azoospermia and micro-TESE failure
Mohamed Wael Ragab ^1,2, Haitham El-Hussieny ³, Hesham Hanafy ^1,2, Ali Mahran ⁴, Mohamed Arafa ^1,5,6
1 Department of Andrology, Cairo University, Cairo, Egypt; ² Dar Al-Nokhba IVF center, Cairo, Egypt; ³ Department of Mechatronics and Robotics Engineering, Egypt-Japan University of Science and Technology (E-JUST), Alexandria, Egypt; ⁴ Department of Andrology, Venereology and Infertility Surgery, Assiut University, Assiut, Egypt; ⁵ Department of Urology, Hamad Medical Corporation, Doha, Qatar; ⁶ Department of Urology, Weill Cornell Medicine-Qatar, Doha, Qatar

08:54 - 09:00

A-0080 Exome and genome sequencing entering routine andrology practice – Estonian experience
Maris Laan ¹, Kristjan Pomm ^2,3, Margus Punab ^1,2,3
1 Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia, Estonia; ² Andrology Clinic, Tartu University Hospital, Tartu, Estonia; ³ Institute of Clinical Medicine, University of Tartu, Tartu, Estonia

08:00 - 08:06

A-0206 Erectile dysfunction and lifestyle: independent role of sleep quality in a large real-world cohort
Davide Menafra ¹, Cristina de Angelis ¹, Francesco Garifalos ¹, Nunzia Verde ¹, Alessandro Mazzarella ¹, Simona Ferazzoli ¹, Eugenio Formisano ¹, Vincenzo Frulio ¹, Simone Rinaldi ¹, Mariangela Piscopo ¹, Tonia Romano ¹, Annamaria Colao ^1,2, Rosario Pivonello ^1,2
1 Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Diabetologia ed Andrologia - Unità di Andrologia e Medicina della Riproduzione, Sessualità e Affermazione di Genere - Università Federico II di Napoli, Naples, Italy; ² Unesco Chair for Health Education and Sustainable Development, Federico II University, Naples, Italy

08:06 - 08:12

A-0236 Maternal serum concentrations of 4-hydroxychlorothalonil during pregnancy and the association with risk of testicular germ cell cancer in male offspring
Cecilie S. Uldbjerg ^1,2, Christian Lindh ³, David M. Kristensen ^1,2,4, Youn-Hee Lim ⁵, Jørgen H. Petersen ^1,2,6, Karina M. Sørensen ⁷, Panu Rantakokko ⁸, Brent A. Coull ⁹, Elvira V. Bräuner ^1,2, Russ Hauser ¹⁰, Niels E. Skakkebæk ^1,2,11, Anders Juul ^1,2,11, Lærke Priskorn ^1,2
1 Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, University of Copenhagen, Denmark; ² International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; ³ Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden; ⁴ Roskilde University, Department of Science and Environment, Roskilde, Denmark; ⁵ Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; ⁶ Section of Biostatistics, Department of Public Health, University of Copenhagen, Denmark; ⁷ Danish National Biobank, Statens Serum Institut, Denmark; ⁸ Department of Public Health, Finnish Institute for Health and Welfare, 70701 Kuopio, Finland; ⁹ Department of Biostatistics, T.H. Chan School of Public Health, Harvard University, USA; ¹⁰ Department of Environmental Health, T.H. Chan School of Public Health, Harvard University, USA; ¹¹ Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

08:12 - 08:18

A-0242 Determinants of androgen abuse withdrawal symptoms: a cross-sectional study of community-dwelling men
Bonnie Grant ¹, Joseph Kean ², Nipun Lakshitha de Silva ^1,3, Rodrigo Aguilera ⁴, Oliver Quinton ¹, Maha Gumssani ¹, Paul Bassett ⁵, Waljit S. Dhillo ¹, Anne Lingford-Hughes ⁶, Kim Wolff ⁴, Channa N. Jayasena ^1
1 Section of Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK; ² BloodWorks Ltd, Bradford, UK; ³ Department of Clinical Sciences, Faculty of Medicine, General Sir John Kotelawala Defence University, Ratmalana, Sri Lanka; ⁴ Drug Control Centre, King’s Forensics, Faculty of Life Science and Medicine, King’s College London, London, UK; ⁵ Statsconsultancy Ltd, Bucks, UK; ⁶ Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK

08:18 - 08:24

A-0246 A Combined Collagenase and Density‑Gradient Method Boosts MicroTESE Outcomes in Non-Obstructive Azoospermia due to SCOS and Maturation Arrest
Marjan Sabbaghian ¹, Elisabetta Piatti ², Marina Bellavia ², Fabrizio Castiglioni ², Franco Nerva ², Giacomo Gazzano ³, Germar-Michael Pinggera ⁴, Giovanni Maria Colpi ^2
1 Dept. of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran; ² Andrology and IVF Center, Next Fertility Procrea, Lugano, Switzerland; ³ Pathology Unit, Istituto Auxologico Italiano IRCCS, Milano, Italy; ⁴ Dept. of Urology, Medical University Innsbruck, Innsbruck, Austria

08:24 - 08:30

A-0261 Global Prevalence of Klinefelter Syndrome in Prenatal Diagnosis: Higher Detection with NIPT Compared to Conventional Methods — A Systematic Review of Temporal Trends and Screening Modalities
Francesco Costantino ^1,2, Antonio Percesepe ^3,4, Riccardo Cuoghi Costantini ⁵, Maria Chiara Decaroli ^1,2, Sara De Vincentis ^1,2, Vincenzo Rochira ^1,2
1 Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; ² Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy; ³ Department of Surgery and Medicine, University Hospital Parma, Italy; ⁴ UO Genetica Medica-University Hospital Parma, Italy; ⁵ Azienda Ospedaliero Universitaria of Modena, Unit of Statistical and Methodological Support to Clinical Research, Modena, Italy

08:30 - 08:36

A-0263 Mosaic loss of Y chromosome as a therapy-induced biomarker of accelerated aging in young oncological patients
Csilla Krausz ¹, Chiara Abrardo ¹, Viola Bonini ¹, Giuseppe Defazio ^1,2, Fabiola Balestri ¹, Daniel Moreno-Mendoza ³, Eduard Ruiz-Castañé ³, Antoni Riera-Escamilla ^3
1 Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy; ² Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, Bari, Italy; ³ Department of Andrology, Fundació Puigvert, Instituto De Investigaciones Biomédicas Sant Pau (IIB-Sant Pau) Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain

08:36 - 08:42

A-0298 Problematic online pornography use and erectile dysfunction
Maurizio De Rocco Ponce ¹, Francesc Maestre ², Ricardo Contreras ¹, Gabino Adalid ¹, Josvany Sanchez Curbelo ¹, Xavier López-i-Martin ³, Josep Castillo-Garayoa ^4
1 Andrology Departament, Fundació Puigvert, Barcelona, Spain; ² Psychology Departament, Fundació Puigvert, Barcelona, Spain; ³ Universidad Oberta de Catalunya, Barcelona, Spain; ⁴ FPCEE Blanquerna, Universitat Ramon Llull, Barcelona, Spain

08:42 - 08:48

A-0300 Cognitive Behavioral Sex Therapy for Patients with Peyronie's Disease: A Pilot Randomized Controlled Trial
Armin Soave ¹, Carla Oltrogge ¹, Martin Sangmeister ², Johannes Moltrecht ¹, Anika Buchholz ³, Amra Pepic ³, Andrea Salzbrunn ⁴, Margit Fisch ¹, Timo O. Nieder ^2
1 Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; ² Institute for Sex Research, Sexual Medicine and Forensic Psychiatry, University Medical Center Ham-burg-Eppendorf, Hamburg, Germany; ³ Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Ham-burg, Germany; ⁴ Department of Andrology, Clinic for Dermatology and Venereology, University Medical Center Ham-burg-Eppendorf, Hamburg, Germany

08:48 - 08:54

A-0015 Role of Steroid Hormone-Binding Proteins on the Bioactivity of 11-Oxygenated Androgens
Jennifer Afrakoma Nyamaah ¹, Astrid Claessens ^1,2, Nick Narinx ^1,3, Karl Storbeck ⁴, Pieter Vermeersch ³, Dirk Vanderschueren ^1,2, Frank Claessens ⁵, Leen Antonio ^1,2
1 Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium; ² Department of Endocrinology, UZ Leuven, Leuven, Belgium; ³ Department of Laboratory Medicine, UZ Leuven, Leuven, Belgium; ⁴ Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa; ⁵ Laboratory of Molecular Endocrinology, KU Leuven, Leuven, Belgium

08:54 - 09:00

A-0049 The bio-psycho-social correlates of male infertility
Anna Juhász ^1,2,3, Balázs Matuszka ⁴, Zsolt Kopa ^2
1 Semmelweis University, Doctoral College, Surgical Medicine Division, Budapest, Hungary; ² Semmelweis University, Department of Urology, Andrology Centre, Budapest, Hungary; ³ Istenhegyi Géndiagnosztikai Centrum, Budapest, Hungary; ⁴ Pázmány Péter Catholic University, Faculty of Humanities and Social Sciences, Institute of Psychology, Budapest, Hungary

08:30 - 09:00

A-0164 The role of the couple in the Andrology field from sexual dysfunction to infertility
Linda Vignozzi
Italy

09:00 - 09:30

A-0165 The Metabolic impact of PDE5 inhibitors: 20 years of trials and Novel findings:
Andrea Isidori
Italy

09:30 - 10:00

A-0304 Unwrapping the sperm chromatin - new insights into protamine functions
Gina E. Merges
Germany

10:00 - 10:10

A-0035 Optimization of in vitro spermiogenesis in the mouse model
Eva Chemin, Laura Moutard, Magali Basille-Dugay, Valentin Rousseau, Ludovic Dumont, Nathalie Rives, Aurélie Feraille, Christine Rondanino
University of Rouen Normandy - Inserm U1239, Rouen, France

10:10 - 10:20

A-0047 Transgenerational effect of endocrine disruptors at subtoxic dosage on male reproductive function
Iva Sabovic ¹, Andrea Di Nisio ², Luca De Toni ¹, Andjela Kovacevic ³, Stefano Gotti ⁴, Carlo Foresta ¹, Alberto Ferlin ^1
1 Department of Medicine, Unit of Andrology and Reproductive Medicine, University of Padova, Padova, Italy; ² Department of Health, Nutrition and Sport, Pegaso Telematic University, Napoli, Italy; ³ Institute of Pathology, Department of Developmental Pathology, Medical Faculty, University of Bonn, Bonn, Germany; ⁴ Neuroscience Institute Cavalieri Ottolenghi (NICO) University of Torino, Torino, Italy

10:20 - 10:30

A-0079 PWWP3B gene variants in male infertility: insights from human genetics, in vitro assays, and a mouse model
Leonie Herrmann ¹, Shoham Kaufman ², Juan Manuel Paturlanne ³, Assiel Rahimy ¹, Sophie Adina Koser ¹, Daniela Fietz ⁴, Jens Rosellen ⁵, Hans-Christian Schuppe ⁵, Sabine Kliesch ⁶, Nina Neuhaus ³, Nitzan Gonen ², Frank Tüttelmann ^1
1 Institute of Reproductive Genetics (IRG), Centre of Medical Genetics (CMG), University of Münster, Münster, Germany; ² Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, Israel; ³ Institute of Reproductive and Regenerative Biology, Centre of Reproductive Medicine and Andrology (CeRA), University Münster, Münster, Germany; ⁴ Institute for Veterinary Anatomy, Histology and Embryology, Justus Liebig University Giessen, Giessen, Germany; ⁵ Clinic and Polyclinic for Urology, Pediatric Urology and Andrology, University Hospital Giessen, Giessen, Germany; ⁶ Department of Andrology, Centre of Reproductive Medicine and Andrology (CeRA), University Hospital Münster, Münster, Germany

10:30 - 10:40

A-0095 Sequencing of the entire X chromosome reveals coding and regulatory variants pointing to novel candidate NOA genes
Viola Bonini ¹, Ginevra Farnetani ¹, Chiara Abrardo ¹, Matteo Vannucci ¹, Eduard Ruiz-Castañé ², Antoni Riera-Escamilla ², Csilla Krausz ^1
1 Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy; ² Department of Andrology, Fundació Puigvert, Instituto De Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain

10:40 - 10:50

A-0240 Transgender-derived testicular tissue as a model for developing anti-fibrotic strategies in Klinefelter syndrome
Emily Delgouffe ¹, Kim Aicha Feryn ¹, Frédéric Chalmel ², Veerle Vloeberghs ³, Guy T'Sjoen ⁴, Herman Tournaye ^1,3, Ellen Goossens ^1
1 Vrije Universiteit Brussel, Brussels, Belgium; ² Université de Rennes, Rennes, France; ³ Universitair Ziekenhuis Brussel, Brussels, Belgium; ⁴ Universitair Ziekenhuis Gent, Ghent, Belgium

10:50 - 11:00

A-0285 Abnormal sperm protamination is linked to reduced Septin12 levels and impaired motility
Ondrej Sanovec ^1,2, Magdalena Tuslova ¹, Ondrej Simonik ¹, Katerina Komrskova ^1,3
1 Institute of Biotechnology of the Czech Academy of Sciences, Vestec, Czech Republic; ² Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic; ³ Department of Zoology, Faculty of Science, Charles University, Prague, Czech Republic

09:30 - 09:42

A-0193 Priapism
Wai Gin (Don) Lee
UK

09:42 - 09:54

A-0194 Infection
Fulvio Colombo
Italy

09:54 - 10:06

A-0195 Corporal Fibrosis
Afonso Morgado
Portugal

10:06 - 10:18

A-0196 Peyronie’s disease
Agustín Fraile
Spain

10:00 - 10:20

A-0171 New insights into FSH receptor signalling
Livio Casarini
Italy

10:20 - 10:40

A-0172 Clinical effects of FSH in male patients with couple infertility
Hussein Kandil
UAE

10:40 - 10:50

A-0139 Deep Phenotyping of Male Infertility Improves the Response to FSH Treatment in Normogonadotropic Oligo-Asthenozoospermia
Giuseppe Grande ¹, Andrea Graziani ^1,2, Alberto Scala ², Nicola Caretta ¹, Antonella Di Mambro ¹, Andrea Garolla ^1,2, Alberto Ferlin ^1,2
1 University Hospital of Padua, Department of Medicine, Unit of Andrology and Reproductive Medicine, Padua, Italy; ² University of Padua, Department of Medicine, Padua, Italy

10:50 - 11:00

A-0122 Intracytoplasmic Sperm Injection Outcomes in Men with High Sperm DNA Fragmentation: Testicular Versus Ejaculated Sperm
Ahmad Majzoub ^1,2, Ahmad Almalki ^1,3, Ahmed Alsaeedi ¹, Kareim Khalafalla ^1,3, Khalid AlKubaisi ^1,3, Sami AlSaid ^1,2, Nadir Fadol ¹, Mohamed Arafa ^1,2,4, Haitham Elbardisi ^1,2,3
1 Urology Department, Hamad Medical Corporation, Doha, Qatar; ² Urology Department, Weill Cornell Medicine-Qatar, Doha, Qatar; ³ Urology Department, Qatar University, Doha, Qatar; ⁴ Andrology Department, Cairo University, Doha, Qatar

10:20 - 10:40

A-0200 Debate - Pro
Giorgio Franco
Italy

10:40 - 11:00

A-0201 Debate - Contra
Sabine Kliesch
Germany

12:00 - 12:30

A-0166 Results from the large Nestorone + testosterone combination gel efficacy trial
Christina Wang
USA

14:00 - 14:20

A-0173 Total and free testosterone measurements in European laboratories
Nick Narinx
Belgium

14:20 - 14:40

A-0174 Variability in SHBG assays and SHBG gene polymorphisms and the effect on cFT
Bruno Lapauw
Belgium

14:40 - 14:50

A-0255 Novel sperm molecular biomarker for selecting spermatozoa with intact DNA
Mikel Albizuri ^1,3, Malen Zabala ³, Ainize Odriozola ^1,2,3, Irune Calzado ^1,2, Manu Araolaza ^1,2, Iratxe Ajuria-Morentin ^2,4, Lorena Crisol ⁵, Maria Aranzazu Guembe ⁵, Roberto Matorras Weining ^2,6, Nerea Subirán ^1,2,3
1 Department of Physiology, University of the Basque Country, Leioa, Bizkaia, Spain; ² Bizkaia Health Research Institute, Barakaldo, Bizkaia, Spain; ³ MEPRO Medical Reproductive Solutions SL, Donostia-San Sebastián, España; ⁴ Galdakao-Usansolo Hospital, Galdakao, Bizkaia, Spain; ⁵ Donostia Hospital, Donostia-San Sebastian, Gipuzkoa, Spain; ⁶ Cruces Hospital, Galdakao, Bizkaia, Spain

14:50 - 15:00

A-0099 Testicular biopsy transcriptomics reveals molecular signatures predictive of negative sperm retrieval in non-obstructive azoospermia
Alexandra Kondic, Sofie Fagerström, Jonatan Axelsson, Angel Elenkov
¹ Lund University, Department of Translational Medicine; ² Skåne University Hospital, Centre of Reproductive Medicine

14:00 - 14:07

A-0188 Management of bone health in the andrological outpatient clinic. Pathophysiology and diagnosis
Sara De Vincentis
Italy

14:07 - 14:14

A-0189 Management of bone health in the andrological outpatient clinic/Therapy. Pathophysiology and diagnosis
Karel David
Belgium

14:14 - 14:29

A-0190 Male Contraception
Cristina Meriggiola
Italy

14:29 - 14:44

A-0191 Testicular Biopsies in Adolescent and Adult Andrological Patients
Niels Joergensen
Denmark

14:00 - 14:20

A-0185 Update on ART outcomes
Edgar Mocanu
Ireland

14:20 - 14:40

A-0186 Impact of male factor on female fertility
Dimitrios Goulis
Greece

14:40 - 15:00

A-0187 Is there a still room for Art in ART?
Luca Gianaroli
Italy

15:00 - 15:30

A-0167 Fetal and Adult Leydig cells: A tale of their origin and fate
Jacques J. Tremblay
Canada

15:30 - 15:33

A-0026 Divergent signaling of LH and hCG through the TSH receptor
Carmela Perri ^1,2, Giada Mercanile ¹, Clara Lazzaretti ¹, Samantha Sperduti ^1,3, Manuela Simoni ^1,3,4, Giulia Brigante ^1,4, Livio Casarini ^1,3
1 Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia. Baggiovara Hospital, Modena, Italy; ² International Ph.D. School in Clinical and Experimental Medicine (CEM) University of Modena and Reggio Emilia, Modena, Italy; ³ Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy; ⁴ Department of Medical Specialties, Azienda Ospedaliero-Universitaria di Modena. Baggiovara Hospital, Modena, Italy

15:33 - 15:36

A-0292 Role of Testosterone Decline in Determining the Symptoms of Functional Hypogonadism Related to Obesity
Bombardieri Alessio ¹, Cotugno Ilaria ¹, Corona Giovanni ², O'Neill Terence W. ³, Bártfai György ⁴, Casanueva Felipe F. ⁵, Forti Gianni ⁶, Giwercman Aleksander ⁷, Han Thang S. ⁸, Slowikowska-Hilczer Jolanta ⁹, Punab Margus ¹⁰, Antonio Leen ¹¹, Vanderschueren Dirk ¹¹, Huhtaniemi Ilpo T., Wu Frederick C. W., Maggi Mario ⁶, Rastrelli Giulia ^1
1 Andrology and Gender Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy; ² Endocrinology and Metabolic Disease Unit, AUSL Romagna, Ospedale Morgagni-Pierantoni, 47121, Forlì (FC), Italy; ³ Centre for Epidemiology Versus Arthritis, Manchester Biomedical Research Centre, The University of Manchester & NIHR, Manchester University NHS Foundation Trust, Manchester, UK; ⁴ Department of Obstetrics, Gynaecology and Andrology, Albert Szent-Gyorgy Medical University, Szeged, Hungary; ⁵ Department of Medicine, CIBER de Fisiopatología Obesidad y Nutricion, Instituto Salud Carlos III, , Santiago de Compostela University, Complejo Hospitalario Universitario de Santiago (IDIS), Santiago de Compostela, CB06/03, Spain; ⁶ Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy; ⁷ Reproductive Medicine Centre, Skåne University Hospital, University of Lund, Lund, Sweden; ⁸ Institute of Cardiovascular Research, Royal Holloway University of London, Egham, Surrey, UK; ⁹ Department of Andrology and Reproductive Endocrinology, Medical University of Łódź, Łódź, Poland; ¹⁰ Andrology Unit, Tartu University Hospital, Tartu, Estonia; ¹¹ Department of Andrology and Endocrinology, KU Leuven, Leuven, Belgium; Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium; ¹² Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Campus, London UK; ¹³ Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Medical and Human Sciences, Institute of Human Development, University of Manchester, Manchester, UK

15:36 - 15:39

A-0237 Low bone mineral density in males from infertile couples - association with reproductive parameters and body mass index. Data from ReproUnion Biobank and Infertility Cohort (RUBIC)
Alexandra Kondic ^1,2*, Sofie Fagerström ^1,2*, Maria Dahlberg ^1,2, Karin Odlén ^1,2, Anders Juul ⁴, Anja Bisgaard Pinborg ⁵, Henriette Svarre Nielsen ^6,7, Sandra Søgaard Tøttenborg ⁸, Johan Malm ³, Aleksander Giwercman ^1,2, Angel Elenkov ^1,2
1 Department of Translational Medicine, Lund University, Malmö, Sweden; ² Reproductive Medicine Centre, Skåne University Hospital, Malmö, Sweden; ³ Department of Chemistry, Skåne University Hospital, Malmö, Sweden; ⁴ Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark; ⁵ Fertility Clinic, Copenhagen University Hospital, Copenhagen, Denmark; ⁶ Department of Clinical Medicine, Copenhagen University Hospital, Copenhagen, Denmark; ⁷ Department of Obstetrics and Gynecology, Copenhagen University Hospital and Amager Hvidovre Hospital, Copenhagen, Denmark; ⁸ Department of Occupational and Environmental Medicine, Bispebjerg and Frederiksberg Hospitals, Denmark

15:39 - 15:42

A-0162 Cardiovascular Risk in Klinefelter Syndrome: Clear Benefits of Testosterone Therapy Despite Residual Excess Mortality - a Swedish register-based Study
Mats Holmberg* ^1,2, Ida Nordgren* ^3,4, Simon Chang ^5,6, Claus Højbjerg Gravholt ^5,6,7, Giorgio Tettamanti ^3,8
1 ANOVA, Karolinska University Hospital, Stockholm, Sweden; ² Department of medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden; ³ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; ⁴ Department of Clinical Genetics and Genomics, Karolinska University Hospital, Stockholm, Sweden; ⁵ Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark; ⁶ Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark; ⁷ Department of Clinical Medicine, Aarhus University; ⁸ Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden

15:42 - 15:45

A-0141 Impact of FSHB and FSHR genes polymorphisms on hormonal profile and sperm retrieval outcome in men with Klinefelter syndrome: a clinical–genetic predictive study
Andrea Graziani ^1,2, Giuseppe Grande ², Maria Santa Rocca ², Massimo Iafrate ³, Riccardo Selice ², Antonella Di Mambro ², Alberto Ferlin ^1,2
1 Department of Medicine, University of Padova, Italy; ² Unit of Andrology and Reproductive Medicine, Department of Systems Medicine, University of Padova, Italy; ³ Unit of Urology, Department of Surgery, Oncology and Gastroenterology, University Hospital of Padova, Padova, Italy

15:45 - 15:48

A-0152 Ultrasound evaluation of testicular volume and correlation with seminal and hormonal parameters in indonesian infertile men: the first Indonesian andrological report
Seso Sulijaya Suyono ^1,2, Rossy Sintya Marthasari ³, Francesco Lotti ^4,5
1 Sadewa IVF Centre Indonesia; ² Gladiool IVF Centre Indonesia; ³ Teratai IVF Centre Indonesia; ⁴ Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy; ⁵ Andrology and Gender Endocrinology Unit, University Hospital Careggi (AOUC), Florence, Italy

15:48 - 15:51

A-0269 Relationship between dynamic penile duplex ultrasound and retinal microcirculation in patients with suspected vascular erectile dysfunction
Matteo Nardin ¹, Paolo Facondo ², Claudia Rossini ³, Luigi Mori ³, Massimo Salvetti ³, Alberto Ferlin ^4,5, Carolina De Ciuceis ³, Andrea Delbarba ^7,8
1 Internal Medicine, Department of Medicine, ASST Spedali Civili di Brescia, Brescia, Italy; ² Unit of Diabetology, Hospital of Gavardo, ASST Garda, Gavardo, Brescia, Italy; ³ Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; ⁴ Department of Medicine, University of Padova, Padova, Italy; ⁵ Department of Systems Medicine, Unit of Andrology and Reproductive Medicine, University Hospital of Padova, Padova, Italy; ⁷ Department of Clinical and Experimental Sciences, Unit of Endocrinology and Metabolism, University of Brescia, Brescia, Italy; ⁸ Unit of Endocrinology and Metabolism, Department of Medicine, ASST Spedali Civili di Brescia, Brescia, Italy

15:51 - 15:54

A-0213 In-depth genetic and phenotypic characterisation of CFTR-associated and CFTR-independent congenital bilateral absence of the vas deferens
Ina Klockner ^1,2, Johanna Steingröver ^1,2, Jann-Frederik Cremers ³, Sabine Kliesch ³, Isabell Schumann ², Frank Tüttelmann ^1,2
1 Institute of Reproductive Genetics (IRG), Centre of Medical Genetics (CMG), University of Münster, Germany; ² Department of Medical Genetics, Centre of Medical Genetics (CMG), University Hospital Münster, Münster, Germany; ³ Department of Andrology, Centre of Reproductive Medicine and Andrology (CeRA), University Hospital Münster, Münster, Germany

15:54 - 15:57

A-0266 CCR6 dysregulation contribute to male infertility by disrupting spermatozoon–oocyte binding
Jin-Chuan Liu ^1,3, Chen Yang ^1,2, Xiaofeng Liu ¹, Siyu Wang ², Xiaoyu Zhang ², Yong Liu ², William Shu-Biu Yeung ^1,3, Jean-Pierre Allam ⁴, Yong-Gang Duan ^1
1 Shenzhen Key Laboratory of Fertility Regulation, Centre of Assisted Reproduction and Embryology, The University of Hong Kong - Shenzhen Hospital, Shenzhen, China; ² Anhui Province Key Laboratory of Embryo Development and Reproduction Regulation, School of Biological and Food Engineering, Fuyang Normal University, Fuyang, China; ³ Department of Obstetrics and Gynaecology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong; ⁴ Department of Andrology, Bonn University Hospital, Bonn, Germany

16:00 - 16:20

A-0175 Obesity and Male Fertility: Looking Beyond Semen Analysis
Andrea Salonia
Italy

16:20 - 16:30

A-0106 Testicular function in young men and risk of cardiometabolic disease up to 20 years later – a register-based follow-up study of more than 5000 men
Laura Smidt Hansen ^1,2, Astrid Linnea Beck ^1,2, Julie Abildgaard ^1,2,3, Anders Juul ^1,2,4, Jørgen Holm Petersen ^1,2,5, Niels Jørgensen ^1,2, Lærke Priskorn ^1,2
1 Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark; ² International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC) Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark; ³ The Centre for Physical Activity research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; ⁴ Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; ⁵ Section of Biostatistics, Department of Public Health, University of Copenhagen, DK-1353 Copenhagen, Denmark

16:30 - 16:40

A-0136 Multiparametric profiling of male infertility: genomic and ultrastructural sperm damage in relation to oxidative stress, age and body mass index
Girolamo Francesca¹, Saracini Giada ¹, Ponchia Rosetta ¹, Boschi Letizia ¹, Barhoumi Mayssa¹, Luongo Francesca Paola², Governini Laura ¹, Morgante Giuseppe ¹, Alice Luddi¹, Paola Piomboni¹\r\n\r\n
¹ Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena,Italy.\r\n² Departmental Faculty of Medicine, Saint Camillus International University of Health Sciences, 00131 Rome, Italy

16:00 - 16:20

A-0176 PRO
Angelo Cignarelli
Italy

16:20 - 16:40

A-0177 CON
Dimitrios Goulis
Greece

16:40 - 16:50

A-0297 Beyond weight loss: tirzepatide directly reprograms the testicular transcriptome in male mice with obesity, diabetes and hypogonadism through a caloric restriction-independent mechanism
Valentina Annamaria Genchi ¹, Celeste Lauriola ¹, Nicola Marrano ¹, Giuseppina Biondi ¹, Annalisa Natalicchio ¹, Sebastio Perrini ², Luigi Laviola ¹, Francesco Giorgino ¹, Angelo Cignarelli ^1
1 Department of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Bari, Italy; ² Section of Endocrinology, Department of Medicine and Surgery, LUM University, Casamassima, Bari, Italy

16:50 - 17:00

A-0241 Online information and testosterone therapy: A global multilingual content analysis
Bonnie Grant ¹, Nipun Lakshitha de Silva ^1,2, Maha Gumssani ¹, Oliver Quinton ¹, Faysal Kayali ³, Isuru Lakmith Gamage ⁴, Waljit S. Dhillo ¹, Mathis Grossmann ^4,5, Channa N. Jayasena ^1
1 Section of Investigative Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK; ² Department of Clinical Sciences, Faculty of Medicine, General Sir John Kotelawala Defence University, Ratmalana 10370, Sri Lanka; ³ Imperial College Healthcare NHS Trust, The Bays, London W2 1NY, UK; ⁴ Department of Endocrinology, Austin Health, Heidelberg, Victoria 3084, Australia; ⁵ Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria 3084, Australia

16:00 - 16:12

A-0197 News in medical therapy
Paolo Capogrosso
Italy

16:12 - 16:24

A-0198 Low-intensity extracorporeal shock wave therapy
Fotios Dimitriadis
Greece

16:24 - 16:36

A-0199 PRP
Eduard Ruiz Casane
Spain

17:00 - 17:20

A-0178 piRNA Dysregulation: Small RNAs, Big Impact on Male Fertility
Kristian Almstrup
Denmark

17:20 - 17:40

A-0179 Couple-Based Genetic Screening: Matching Carriers to Uncover Recessive Risks in Male Infertility
Antonio Capalbo
Italy

17:40 - 17:50

A-0215 Association of Spermatozoal RNA Expression with Fertilization Outcomes in ART
Thomas Greither, Lina Albrecht, Diana Handke, Ivan Hoffmann, Hermann M. Behre
Center for Reproductive Medicine and Andrology, University Medicine Halle, Halle (Saale), Germany

17:50 - 18:00

A-0022 Identification of whole exome sequencing derived spermatogenic gene associated copy number variants in idiopathic hypospermatogenesis patients
Nisha Sharma ¹, Ashutosh Halder ¹, Seema Kaushal ², Manoj Kumar ³, Manish Jain ^1
1 Department of Reproductive Biology, All India Institute of Medical Sciences New Delhi, India; ² Department of Pathology, All India Institute of Medical Sciences New Delhi, India; ³ Department of Urology, All India Institute of Medical Sciences New Delhi, India

17:00 - 17:06

A-0222 Is 'Living Apart Together' a real advantage for patients consulting for sexual dysfunction? A cohort study
Clotilde Sparano ¹, Giovanni Corona ², Giulia Rastrelli ³, Linda Vignozzi ³, Daniele Vignoli ⁴, Mario Maggi ^1
1 Endocrinology Unit, 'Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; ² Endocrinology Unit, Azienda AUSL, Maggiore Hospital, Bologna, Italy; ³ Andrology, Women's Endocrinology and Gender Incongruence Unit, 'Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; ⁴ Department of Statistics, Computer Science, Applications, University of Florence, Florence, Italy;

17:06 - 17:12

A-0262 Sex steroids measurement by mass spectrometry in hypogonadal men in a real-world setting: serum estradiol (E2) and E2 to Total Testosterone (TT) ratio do not differ between patients with Klinefelter Syndrome (KS) and non-KS hypogonadism
Sara Cerrato ¹, Daniele Renda Livraghi ¹, Francesco Costantino ^1,3, Filippo Vignali ¹, Giulia Canu ², Maria Cristina De Santis ², Laura Roli ², Tommaso Fasano ², Sara De Vincentis ^1,3, Vincenzo Rochira ^1,3
1 Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; ² Department of Laboratory Medicine and Pathology, Azienda USL of Modena, Modena, Italy; ³ Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria di Modena, Ospedale Civile di Baggiovara, Modena, Italy

17:12 - 17:18

A-0271 Measuring the prevalence of gender identities according to XYGO in a non-clinical sample of Italian people
Andrea Sansone ¹, Elena Colonnello ¹, Tommaso B Jannini ², Emmanuele A. Jannini ^3
1 Section of Endocrinology and Medical Sexology (ENDOSEX) Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; ² Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy; ³ Chair of Endocrinology and Medical Sexology (ENDOSEX) Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

17:18 - 17:24

A-0030 Concentration Matters: Prevalence Of Genetic Disorders Is Associated With The Severity of Seminal Abnormalities
Jose Ignacio Vinay ^1,2,3, Ricardo Sobell ², Mauricio Andriola ², Joaquin Sanhueza ^2
1 Uros Associats Teknon, Barcelona, Spain; ² Faculty of Medicine, University of Chile, Santiago, Chile; ³ Shady Grove Fertility, Santiago, Chile

17:24 - 17:30

A-0070 A shared language of life: conserved essential proteins underlying mammalian fertilisation
Emilie Zeine ¹, Laurence Stouvenel ¹, Marine Foritano ¹, Ahmed Ziyyat ^1,2
1 Université Paris Cité, CNRS, INSERM, Institut Cochin, Paris, France; ² Service d'Histologie, d'Embryologie, Biologie de la reproduction, AP-HP, Hôpital Cochin, Paris, France

17:30 - 17:36

A-0278 Are Large Language Models Ready for Clinical Explainability in Andrology? Insights from a Clinician-Based Evaluation
Moreno La Quatra ¹, Francesco Pallotti ², Giorgia Spaggiari ³, Daniele Santi ³, Nicole Dalia Cilia ^1
1 University of Enna "Kore", Department of Engineering and Architecture, Enna, Italy; ² University of Enna "Kore", Department of Medicine and Surgery, Enna, Italy; ³ University of Modena and Reggio Emilia, Department of Biomedical, Metabolic and Neural Sciences, Modena, Italy

17:36 - 17:42

A-0007 Spermatic cord block as a treatment modality in chronic scrotal pain: a tertiary referral center study
Massimiliano Raffo, Josvany Rene Sanchez Curbelo, Maurizio De Rocco Ponce, Luis Malca Caballero, Jose Antonio Arrus Soldi, Ricardo Contreras Garcia, Sebastian Dumas, Gabi Adalid, Eduard Ruiz-Castane, Doron Vantman Luft
Fundacio Puigvert, Barcelona, Spain

17:42 - 17:48

A-0086 Impact of chemotherapy regimens on spermatogonia subpopulations and somatic cells in (pre)pubertal boys’ testicular tissue prior to cryopreservation
Valentin Rousseau ¹, Nathalie Rives ^1,2, Manon Charles ¹, Magali Basille-Dugay ¹, Caroline Neusius ², François Fraissinet ^1,3, Eva Chemin ¹, Marion Dufour ^1,2, Hugo Dupuis ^1,2, Christine Rondanino ¹, Aurélie Feraille ^1,2, Ludovic Dumont ^1
1 Univ Rouen Normandie, INSERM, NORDIC UMR 1239 – Team Adrenal and Gonadal Pathophysiology (AGoPath), Rouen, France; ² Rouen University Hospital, Department of Biology of Reproduction-CECOS laboratory, Rouen, France; ³ Rouen University Hospital, Department of General Biochemistry, Rouen, France

17:48 - 17:54

A-0112 Molecular Characterization of a Microtubule-Associated Protein in Human Sperm and Its Association with Asthenozoospermia
Adli Othamne ¹, Ezzahra Rachid ³, Kbirou Adil ^1,2, Aboutaieb Rachid ^1,2
1 Laboratory of Sexual and Reproductive Health, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco; ² Department of Urology, Ibn Rochd University Hospital Center, Casablanca, Morocco; ³ Science & Engineering of Biomedicals, Biophysics and Health Laboratory, Higher Institute of Health Sciences, Hassan First University of Settat, Morocco

17:54 - 18:00

A-0118 Novel compound heterozygous SPAG17 variants cause human male infertility through multiple morphological abnormalities of spermatozoal flagella
Peng Ge, Jianpeng Zheng, Junqi Wang
Department of Urology, The Affiliated Hospital of Xuzhou Medical University, 221002 Xuzhou, Jiangsu, China

17:00 - 17:12

A-0202 Hormonal treatment of transgender and non-binary persons
Justine Defreyne
Belgium

17:12 - 17:24

A-0203 Attitudes of transgender and gender-diverse adolescents and their parents on parenthood and fertility preservation before starting hormone therapy
Tessa Stolk
The Netherlands

17:24 - 17:36

A-0204 Surgical management of transgender and non-binary persons
Andrea Cocci
Italy

17:36 - 17:48

A-0205 Law, policy and ethics of transgender and non-binary persons
Angelo Schillaci
UK

08:00 - 08:06

A-0277 The effect of treatment with aromatase inhibitors on sexual desire in men: a meta-analysis
Giovanni Corona ¹, Giulia Rastrelli ², Clotilde Sparano ³, Linda Vignozzi ², Alessandra Sforza ⁴, Mario Maggi ^3
1 Endocrinology and Metabolic Diseases, AUSL Romagna, Forli'-Cesena, Italy; ² Andrology and Gender Endocrinology Unit, Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; ³ Endocrinology Unit, Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; ⁴ Endocrinology Unit, Azienda AUSL, Maggiore Hospital, Bologna, Italy

08:06 - 08:12

A-0235 Early Life Stress Reprograms Hippo Signaling in the Testis Despite Increased Body Growth: Converging Evidence from Developmental and Mechanistic Models
İrem İnanç ¹, Onur Bender ², Ekin Baysal ³, Arzu Atalay ², Esra Erdemli ^1
1 Ankara University, Faculty of Medicine, Department of Histology and Embryology, Ankara, Turkey; ² Ankara University, Biotechnology Institute, Ankara, Turkey; ³ İstanbul University, Faculty of Medicine, Department of Histology and Embryology, İstanbul, Turkey

08:12 - 08:18

A-0076 Differential proteomic maturity in sperm cells subjected to selection procedures in couples with unexplained infertility
Marina Leiva ¹, Meritxell Jodar ^1,2, Maria Corredor ¹, Mar Domingo ¹, Marta Guimerà ³, Aina Borràs ^3,4, Dolors Manau ^3,4, Juan Manuel Corral ⁵, Judit Castillo ¹, Rafael Oliva ^1,2
1 Molecular Biology of Reproduction and Development Research Group, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Fundació de Recerca Clínic Barcelona (FRCB), Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain; ² Biochemistry and Molecular Genetics Service, Hospital Clínic Barcelona, Barcelona, Spain; ³ Gynecology, Obstetrics and Neonatology Clinical Institute (ICGON), Hospital Clínic Barcelona, Barcelona, Spain; ⁴ Gynecology, Human Reproduction and Women´s Health Research Group, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; ⁵ Urology Service, Andrology Unit, Nephrology and Urology Clinical Institute (ICNU), Hospital Clínic Barcelona, Barcelona, Spain

08:18 - 08:24

A-0126 Anti-Müllerian hormone and surgical sperm retrieval in nonobstructive azoospermia: an aetiology-specific systematic review and meta-analysis
Carlo Pisanò, Daniele Tienforti, Claudio Capuano, Elisa Cocci, Luca Spagnolo, Arcangelo Barbonetti
Andrology Unit, Hospital S. Salvatore, Department of Medical, Health, Life and Ambiental Sciences, University of L'Aquila, L'Aquila, Italy

08:24 - 08:30

A-0130 Human testicular germ cell tumours: evolving links between immune landscape and specialized vascularisation
Nina Ihring ¹, Leonie Amann ^1,2, Pia Holtkamp ¹, Miriam Figura ¹, Ayele T. Tsedeke ¹, Jens Rosellen ², Federico Lanza ², Monika Fijak ^3,4, Hiba Hasan ³, Daniela Fietz ^1,4, Hans-Christian Schuppe ^2,4
1 Institute for Veterinary Anatomy, Histology and Embryology, Justus Liebig University Giessen, Germany; ² Dept. of Urology, Paediatric Urology and Andrology, Justus Liebig University Giessen, Germany; ³ Institute for Anatomy and Cell Biology, Justus Liebig University Giessen, Germany; ⁴ Hessian Centre for Reproductive Medicine (HZRM) Justus Liebig University Giessen, Germany

08:30 - 08:36

A-0256 Proteomic profiling reveals energy metabolism disruptions in unexplained male infertility
Nerea Subirán ^1,2, Itziar Urizar-Arenaza ^1,2, Beatriz Navarro Santos ³, Manu Araolaza ^1,2
1 Department of Physiology, University of the Basque Country, Leioa, Bizkaia, Spain; ² Biocruces-Bizkaia Health Research Institute, Barakaldo, Spain; ³ Quirón Bilbao, Assisted Reproductive Unit, Bilbao, Spain

08:36 - 08:42

A-0098 Beyond biology: Social determinants shaping male sexual health and andrology care pathways in Morocco
Khadija Hidous ¹, Rachid Aboutaieb ^1,2, Houssine Boufettal ^1,2
1 Laboratory of Sexual and Reproductive Health, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco; ² Urology Department, Ibn Rochd Hospital, Casablanca, Morocco

08:42 - 08:48

A-0109 Genotypic Distribution of High-Risk Human Papillomavirus and Its Association with Sexually Transmitted Infection Coinfections in Men Attending a Sexual Health Center in Lima, Peru
Gustavo A. Grandez-Castillo ¹, Olenka Farfan-Zapata ¹, Guido Bendezu-Quispe ², J. Antonio Grandez-Urbina ^1
1 Insalud Research, Lima, Peru; ² Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Vicerrectorado de Investigación, Universidad San Ignacio de Loyola, Lima, Peru

08:48 - 08:54

A-0119 Does Sperm Source Matter in Cryptozoospermia? A Comparison of Testicular and Ejaculated Sperm for ICSI
Mohamed Arafa ^1,2,3, Kareim Khalafalla ^1,4, Nadir Fadol ¹, Ahmad Almalki ^1,4, Sami AlSaid ¹, Khalid Alkubaisi ¹, Ahmed AlSaeedi ¹, Haitham Elbardisi ^1,2,4, Ahmad Majzoub ^1,2
1 Urology Department, Hamad Medical Corporation, Doha, Qatar; ² Urology Department, Weill Cornell Medicine-Qatar, Doha, Qatar; ³ Andrology Department, Cairo University, Doha, Qatar; ⁴ Urology Department, Qatar University, Doha, Qatar

08:54 - 09:00

A-0210 TRANSCEND-XR: Improving knowledge of late treatment effects among adolescent and young adult testicular cancer survivors
Davor Ježek ¹, Maria O’Malley ², Josephine Hegarty ², Ismail Toygar ², Maria Inês Clara ², Jack P. Gleeson ^3,4, David Murphy ⁵, Sheena McHugh ⁶, Frances Shiely ^6,7, Aileen Murphy ⁸, Ann Kirby ⁸, Ida J. Korfage ⁹, Sophie Terhaard ⁹, Agnes van der Heide ⁹, Aisha Hussain ¹⁰, Matias Katajavaara Seidler ¹⁰, Lynda Corrigan ¹¹, Patrice Kearney Sheehan ¹¹, Daniele Raggi ¹², Alison Reid ¹², Michal Chovanec ^13,14, Patrizia Gianntempo ¹⁵, Jourik A. Gietema ¹⁶, Justine Fleur van der Feen ¹⁷, Francisco Lupiáñez-Villanueva ¹⁷, Ana Roca-Umbert ¹⁷, Joanne Reid ¹⁸, Paulo Alves ^19,20, Joana Soares ²¹, Karen Galvin ²¹, Michal Kubo ²², Adeline Salasc ²³, Anna Patrikidou ²⁴, Mohamad M. Saab ^2
1 School of Medicine, University of Zagreb, Centre of Excellence for Reproductive and Regenerative Medicine, Zagreb, Croatia; ² Catherine McCauley School of Nursing and Midwifery, University College Cork, Cork, Ireland; ³ Cancer Research @UCC, College of Medicine and Health, University College Cork, Cork, Ireland; ⁴ Cork University Hospital/University College Cork Cancer Centre, Cork University Hospital, Cork, Ireland; ⁵ School of Computer Science and Information Technology, University College Cork, Cork, Ireland; ⁶ School of Public Health, University College Cork, Cork, Ireland; ⁷ Health Research Board Clinical Research Facility, University College Cork, Cork, Ireland; ⁸ Department of Economics, Cork University Business School, University College Cork, Cork Ireland; ⁹ Erasmus MC, University Medical Center Rotterdam, Department of Public Health, Rotterdam, the Netherlands; ¹⁰ Khora, Copenhagen, Denmark; ¹¹ Tallaght University Hospital, Dublin, Ireland; ¹³ 2nd Department of Oncology, Faculty of Medicine, Comenius University and National Cancer Institute, Bratislava, Slovakia; ¹⁴ Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia; ¹⁵ Fondazione Irccs Istituto Nazionale Dei Tumori, Milan, Italy; ¹⁶ Academisch Ziekenhuis Groningen, Groningen, the Netherlands; ¹⁷ PredictBy Research and Consulting, Barcelona, Spain; ¹⁸ The School of Nursing and Midwifery, Queen’s University Belfast, United Kingdom; ¹⁹ Center for Interdisciplinary Research in Health, Faculty of Health Sciences and Nursing, Catholic University of Portugal, Porto, Portugal; ²⁰ School of Nursing, Catholic University of Portugal, Porto, Portugal; ²¹ FundtoInnovate Limited, Cork, Ireland; ²² Association of European Cancer Leagues, Brussels, Belgium; ²³ Gustave Roussy, Villejuif, France; ²⁴ Genito-urinary Oncology Team, Department of Medical Oncology and Drug Development Department, Gustave Roussy, France

08:00 - 08:06

A-0074 Testicular ultrasound inhomogeneity: clinical, seminal, hormonal and ultrasound correlates
Francesco Lotti ^1,2, Benedetta Batisti ^1,2, Michele Bertolotto ^3
1 Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy; ² Andrology and Gender Endocrinology Unit, University Hospital Careggi (AOUC), Florence, Italy; ³ Department of Radiology, University of Trieste, Ospedale di Cattinara, Trieste, Italy

08:06 - 08:12

A-0025 Erectile dysfunction and physical comorbidities in young men, a population-based cohort study
Anastasios Fylaktos ^1,2, Hans Järnbert-Pettersson ³, Mats Holmberg ^3,4, Jussi Jokinen ^5,6, Cecilia Ekéus ^1
1 Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden; ² ANOVA, Andrology, Sexual medicine, Trans medicine, Karolinska University Hospital, Stockholm, Sweden; ³ Department of Clinical Science and Education, Södersjukhuset, Karolinska Institute, Stockholm, Sweden; ⁴ Department of Medicine, Huddinge, Karolinska Institute, Stockholm, Sweden; ⁵ Department of Clinical Sciences, Psychiatry, Umeå University, Sweden; ⁶ Department of Clinical Neuroscience, Karolinska Institute, Sweden

08:12 - 08:18

A-0217 Super-resolution microvascular ultrasound is a novel and highly sensitive testicular functional imaging modality when tested in men with testicular dysfunction
Nikoleta Papanikolaou ¹, Jipeng Yan ², Biao Huang ², Rhianna Davies ¹, Cara Go ¹, Waljit S. Dhillo ¹, Suks Minhas ³, Adrian KP Lim ⁴, Meng-Xing Tang ², Channa N Jayasena ^1
1 Division of Diabetes, Endocrinology and Metabolism, Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK; ² Department of Bioengineering, Imperial College London, London, UK; ³ Department of Urology, Charing Cross Hospital, London, UK; ⁴ Department of Imaging, Imperial College London and Healthcare NHS Trust, Charing Cross Hospital Campus, London, UK

08:18 - 08:24

A-0068 Seminal plasma HSPA2 as a non-invasive biomarker to distinguish Sertoli cell-only syndrome from mixed testicular atrophy in non-obstructive azoospermia
Raouda Sgaier ¹, Hans-Christian Schuppe (2, 3), Adrian Pilatz ², Jens Rosellen ², Thorsten Diemer ², Daniela Fietz (1, 3)
¹ Institute for Veterinary Anatomy, Histology and Embryology, Justus Liebig University Giessen, Giessen, Germany; ² Clinic and Polyclinic for Urology, Pediatric Urology and Andrology, University Hospital Giessen, Giessen, Germany; ³ Hessian Centre for Reproductive Medicine (HZRM), Justus Liebig University Giessen, Giessen, Germany

08:24 - 08:30

A-0089 High glucose supplementation aggravates experimental autoimmune epididymo-orchitis via localized Th17 skewing in the male reproductive tract
Jin-Chuan Liu^1,2, Qun-Xiong Zeng², Fu Shi¹, Jiangxia Shi¹, Minmin Lyu¹, Yu Li¹, Yong-Gang Duan^1
1 Shenzhen Key Laboratory of Fertility Regulation, Center of Assisted Reproduction and Embryology, The University of Hong Kong - Shenzhen Hospital, Shenzhen, China; ² Department of Obstetrics and Gynecology, the University of Hong Kong, Pokfulam Road, Hong Kong, China;

08:30 - 08:36

A-0279 Comparison of Functional and Anatomical Outcomes of Grafting and Combined (Graft and Tunical Shortening) Techniques in the Surgical Treatment of Peyronie's Disease
M. Firat Ozervarli, Fatih Ozdemir, Mert Emre Erden, Serhat Aksoy, Kaan Kutay Baser, Murat Dursun, Mazhar Ortaç, Ateş Kadıoglu
Istanbul University Istanbul Faculty of Medicine, Department of Urology, Istanbul, Turkey

08:36 - 08:42

A-0107 Global prevalence of recreational use of phosphodiesterase type 5 inhibitors: a systematic review and meta-analysis
Luca Spagnolo, Daniele Tienforti, Carlo Pisanò, Elisa Cocci, Matteo Civilla, Arcangelo Barbonetti
Andrology Unit, Hospital S. Salvatore, Department of Medical, Health, Life and Ambiental Sciences, University of L'Aquila, L'Aquila, Italy

08:42 - 08:48

A-0132 Dietary associations with sperm DNA fragmentation in men from infertile couples: Swedish RUBIC data
Viktor Svensson ^1,2, Aleksander Giwercman ^1,3, Henriette Svarre Nielsen ⁴, Jonatan Axelsson ^1,3
1 Reproductive Medicine Centre, Skåne University Hospital Malmö, Sweden; ² Faculty of Medicine, Lund University, Sweden; ³ Reproductive Medicine, Department of Translational Medicine, Lund University, Sweden; ⁴ Department of Clinical Medicine, Obstetrics and Gynaecology, University of Copenhagen, Denmark

08:48 - 08:54

A-0154 Performance of an AI real-time detection model compared with computer-aided sperm analysis for sperm concentration
Trine B. Haugen ¹, Pål A. H. Bentsen ¹, Mario Iliceto ², Eldri U. Due ¹, Mette H. Stensen ², David Mortimer ³, Vajira Thambawita ^1,4, Jorunn M. Andersen ^1
1 Department of Life Sciences and Health, Oslo Metropolitan University, Oslo, Norway; ² Volvat Spiren Oslo, Oslo, Norway; ³ Oozoa Biomedical, West Vancouver, BC, Canada; ⁴ Simula Metropolitan Center for Digital Engineering, Oslo, Norway

08:54 - 09:00

A-0143 Semen quality in transgender individuals seeking fertility preservation
Maurizio De Rocco Ponce ¹, Eden Troka ², Massimiliano Raffo ^3,4, Luis Miguel Malca Caballero ¹, Alberto Ferlin ², Andrea Salonia ³, Eduard Ruiz Castañé ¹, Alberto Scala ², Andrea Garolla ^2
1 Fundación Puigvert, Andrology Department, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau) Barcelona, Spain; ² Unit of Andrology and Reproductive Medicine, Department of Medicine (DIMED) University of Padua, Padua, Italy; ³ Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; ⁴ University Vita-Salute San Raffaele, Milan, Italy

09:00 - 09:30

A-0192 Seminal fluid effects on uterine receptivity to embryo implantation: transcriptomic strategies to define molecular mechanisms
Sarah Robertson
Australia

09:30 - 10:00

A-0169 Are We Propagating Infertility Through IVF? Genetic Insights into HerITbility
Csilla Krausz
Italy

10:00 - 10:03

A-0264 Longitudinal Changes in Bone Mineral Density (BMD) in Patients with Klinefelter Syndrome (KS): A Prospective Observational Study in a Real-world setting
Filippo Vignali ¹, Francesco Costantino ^1,2, Daniele Renda Livraghi ¹, Veronica Maria Denichelis ¹, Sara De Vincentis ¹, Vincenzo Rochira ^1,2
1 Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; ² Unit of Endocrinology, Department of Medical Specialties, Azienda OspedalieroUniversitaria of Modena, Modena, Italy

10:03 - 10:06

A-0286 Persistent Sexual and Psychological Symptoms after Finasteride Discontinuation: A Cross-Sectional Observational Study (under peer review)
Paweł Jędrzejczyk, Tomasz Ząbkowski, Jarosław Ratajski, Kamil Ciechan, Tomasz W. Kaminski, Patryk Uciechowski, Tomasz Syryło
¹ GEN Clinic, Warsaw, Poland; ² Military Institute of Medicine – National Research Institute, Warsaw, Poland; ³ Bielanski Hospital, Warsaw, Poland; ⁴ Versiti Blood Research Institute, Milwaukee, USA

10:06 - 10:09

A-0111 From Methylation to Metabolism: Epigenetic Regulation of IDH3A and Its Significance in Prostate Cancer — An In Silico Perspective
Rachid Ezzahra ^1,2, Adli Othmane ³, Kbirou Adil ⁴, Aboutaieb Rachid ^3,4, Abboussi Oualid ^2
1 Science & Engineering of Biomedicals, Biophysics and Health Laboratory, Higher Institute of Health Sciences, Hassan First University of Settat, Morocco; ² Physiology and Physiopathology Team, Faculty of Sciences, Genomic of Human Pathologies Research Centre, Mohammed V University, Rabat, Morocco; ³ Laboratory of Sexual and Reproductive Health, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco; ⁴ Department of Urology, Ibn Rochd University Hospital Center, Casablanca, Morocco

10:09 - 10:12

A-0134 Seasonal Variation in Semen Parameters: A Retrospective Study of 2428 Semen Samples
Aleksei Ryzhkov ¹, Svetlana Sokolova ², AlexandraVasileva ¹, Sofia A. Bushueva ¹, Igor Shormanov ^1
1 Yaroslavl State Medical University, Yaroslavl, Russia; ² Mother and Child Clinic, Yaroslavl, Russia

10:12 - 10:15

A-0150 Artificial intelligence–based semen analysis versus expert manual spermogram: a comparative study
Iurii Arian, Andrei Chiriac, Victoria Nofit, Anastasia Ambros, Victoria Ghenciu, Ion Dumbraveanu
Lab of Urology, Andrology and Reproductive Medicine, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova

10:15 - 10:18

A-0085 Clinical Hormonal Outcomes of Clomiphene Citrate in Mexican Men With Functional Hypogonadism and Infertility: A Three-Month Paired Analysis
Andrés Mora Topete ¹, Moises Abraham Adel Domínguez ^2
1 Centro de Uro Andrología, Guadalajara, Jalisco, México

10:18 - 10:21

A-0248 Oxidative stress and DNA integrity alterations induced by methotrexate in human spermatozoa and the protective effect of metformin: an in vitro experimental study
Amira Sallem ^1,2, Amira Dhaoui ^1,2, Manel Boussabbeh ¹, Faouez Boujelben ¹, Narjes Trabelsi ¹, Ranin Selmi ^1,2, Elhem Ghodhbane ¹, Meriem Mehdi ^1
1 Department of Reproductive Biology, Maternity and Neonatology Center of Monastir, Fattouma Bourguiba University Teaching Hospital, Monastir, Tunisia; ² Research Laboratory 'Environment, Inflammation, Signaling and Pathologies' (LR18ES40) Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia

10:21 - 10:24

A-0050 A spatiotemporal multimodal atlas of human genital tubercle reveals fine cellular organization and cell-type-specific sex-biased genes associated with disorders of sex development
Antonio Suglia ¹, Bertrand Evrard ¹, Laurianne Lesné ¹, Maryne Toupin ¹, Aurélie Lardenois ¹, Paul Rivaud ¹, Alain Chédotal ^2,3,4, Terje Svingen ⁵, Antoine Dominique Rolland ¹, Séverine Mazaud-Guittot ¹, Frédéric Chalmel ^1
1 Irset (Institut de recherche en santé, environnement et travail), Rennes, France; ² Institut de la Vision, Paris, France; ³ Institut de pathologie groupe hospitalier Est, hospices civils de Lyon, France; ⁴ University Claude Bernard, Lyon, France; ⁵ Technical University of Denmark, Lyngby, Denmark

10:30 - 10:50

A-0180 Androgen deprivation and body composition changes
Andrea Berruti
Italy

10:50 - 11:10

A-0303 Beyond androgen suppression: estrogen deprivation effects in prostate cancer
Channa Jayasena
UK

11:10 - 11:20

A-0045 Longitudinal changes in reproductive hormones prior to clinical diagnosis of a testicular germ cell tumour
Nina Mørup ^1,2, Trine Holm Johannsen ^1,2,3, Gedske Daugaard ⁴, Hanne Frederiksen ^1,2, Jørgen Holm Petersen ^1,2,5, Michael Schwinn ⁶, Mette Skou Bentsen ⁶, Jakob T Bay ⁷, Henrik Ullum ⁸, Bertram Dalskov Kjerulff ^9,10, Kathrine Agergård Kaspersen ¹⁰, Christian Erikstrup ^9,10, Erik Sørensen ⁶, Sisse Rye Ostrowski ^6,11, Ole Birger Pedersen ^7,11, Kristian Almstrup ^1,2,12, and Anders Juul ^1,2,11
1 Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Denmark; ² The International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health, Copenhagen, Denmark; ³ Department of Clinical Biochemistry, Copenhagen University Hospital – Rigshospitalet, Denmark; ⁴ Department of Oncology, Copenhagen University Hospital – Rigshospitalet, Denmark; ⁵ Section of Biostatistics, University of Copenhagen, Denmark; ⁶ Department of Clinical Immunology, Copenhagen University Hospital – Rigshospitalet, Denmark; ⁷ Department of Clinical Immunology, Zealand University Hospital – Køge, Denmark; ⁸ Statens Serum Institut, Copenhagen, Denmark; ⁹ Department of Clinical Medicine, Aarhus University, Denmark; ¹⁰ Department of Clinical Immunology, Aarhus University Hospital, Denmark; ¹¹ Department of Clinical Medicine, University of Copenhagen, Denmark; ¹² Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark

11:20 - 11:30

A-0142 A Stepwise Imaging Framework for Testicular Lesions: when to observe, when to preserve, when to operate. Insights from a 20-Year Single-Center Experience
Marta Tenuta ¹, Francesco Carlomagno ¹, Franz Sesti ¹, Francesco Angelini ¹, Giulia Pellegrini ¹, Daniele Apostoli ¹, Lucia Manganaro ², Giorgio Franco ³, Gabriele Savarese ³, Fabio Massimo Magliocca ², Daniele Gianfrilli ¹, Andrea Isidori ¹*, Carlotta Pozza ¹*
¹ Department of Experimental Medicine, Sapienza University, Rome, Italy; ² Department of Radiological, Oncological and Pathological Sciences, Sapienza University, Rome, Italy; ³ Department of Maternal and Child Health and Urological Sciences, Sapienza University, Rome, Italy

10:30 - 10:50

A-0181 Genotyping, sperm handling, LAISS, embryo quality and ICSI outcome
Kaylee Holleman
The Netherlands

10:50 - 11:00

A-0096 Investigating the interaction between Perinuclear theca and GARIN proteins in sperm development and male fertility in mice
Andjela Kovacevic, Kathrin Burckhardt, Joana Gerstenberg, Simon Schneider, Gina E. Merges, Hubert Schorle
University of Bonn, University Hospital Bonn, Institute of Pathology, Department of Developmental Pathology

11:00 - 11:10

A-0071 Human stem cell-derived Sertoli-like cells recapitulate early Sertoli cell transcriptomic signatures
Mathangi Lakshmipathi ^1,2, Saskia K. M. van Daalen ^1,2, Cindy M. de Winter- Korver ^1,2, Ans M. M. van Pelt ^1,2, Geert Hamer ^1,2, Callista L. Mulder ^1,2
1 Reproductive Biology Laboratory, Center for Reproductive Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands; ² Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands

10:30 - 10:44

A-0231 Region-Specific Macrophage – Epithelial Crosstalk Shapes Epididymal Homeostasis
Tiziana Grimaldini ¹*, Julia König ²*, Vishnu Kumar ³, Marek Bartkuhn ³, Sudhanshu Bhushan ¹, Denise Messerer ⁴, Christian Schulz ⁵, Christiane Pleuger ¹, Andreas Schlitzer ²*, Andreas Meinhardt ¹*
¹ Institute of Anatomy and Cell Biology, Justus-Liebig-University of Giessen, Giessen, Germany; ² Life & Medical Sciences, Biology of Inflammation, University of Bonn, Bonn, Germany; ³ Biomedical Informatics and Systems Medicine Science Unit for Basic and Clinical Medicine, Justus-Liebig University of Giessen, Giessen, Germany; ⁴ Medical Clinic and Polyclinic, Ludwig-Maximilians University Munich, Munich, Germany; ⁵ Institute for Innate Immunoscience, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

10:44 - 10:58

A-0232 Urinary metabolites of selected non-persistent endocrine-disrupting chemicals and sperm DNA fragmentation in young men from the general population
Renata Walczak-Jedrzejowska ¹ , Joanna Jurewicz ², Wojciech Hanke³, Bartosz Wielgomas ⁴, Katarzyna Marchlewska ¹, Jolanta Slowikowska-Hilczer ^1
1 Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, Lodz, Poland; ² Department of Chemical Safety, Nofer Institute of Occupational Medicine, Lodz, Poland; ³ Department of Occupational Diseases and Environmental Health, Nofer Institute of Occupational Medicine, Lodz, Poland; ⁴ Department of Toxicology, Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland

10:58 - 11:12

A-0233 Artificial intelligence improves prediction of sperm retrieval success in non-obstructive azoospermia
Zsolt Kopa ¹, József Bokor ², Anett Szabó ^1
1 Semmelweis University, Budapest, Hungary; ² MTA SZTAKI, Budapest, Hungary

11:12 - 11:26

A-0013 Sub-Gluteal Ligation of the Internal Pudendal Vein for Management of Veno-Occlusive Erectile Dysfunction (Shaeer's Vein Ligation–I): The Cadaveric Study
Osama Shaeer ^1,2, Ehab A. A. El-Shaarawy ³, Hossam Y. Emam ³, Islam Elsisi ¹, Eslam Sokar ¹, Kamal Shaeer ^1
1 Department of Andrology, Kasr El Aini Faculty of Medicine, Cairo University, Egypt; ² The Middle East Society for Sexual Medicine; ³ Department of Anatomy and Embryology, Kasr El Aini Faculty of Medicine, Cairo University, Egypt

11:30 - 11:50

A-0182 PRO
Giulia Rastrelli
Italy

11:50 - 12:10

A-0183 CON
Michael Zitzmann
Germany

12:10 - 12:20

A-0032 Hypercortisolism and Male Hypogonadism: what is the role of Mild Autonomous Cortisol Secretion
Alessandro Ciarloni, Silvia Rossi, Michele Perrone, Nicola Ambo, Valentina Di Giacomi, Carlo Mazza, Marianna Martino, Gilberta Giacchetti, Gianmaria Salvio, Giancarlo Balercia
Clinica di Endocrinologia e Malattie del Metabolismo, Dipartimento di Scienze Cliniche e Molecolari, Ancona, Italy

12:20 - 12:30

A-0229 Comparative study between the effects of weight loss by Sleeve gastrectomy surgery versus liraglutide on male fertility
Mohamed Hassan Ali Fahmy ³, Mohamed Abdul Moneim Amin El Masry ³, Mina Saad ^1,2, Ehab Fathy Ahmed ³, Mohamed Mahmoud Saleh ³, Mohamed Wael Ragab ^1,2
1 Department of Andrology, Cairo University, Cairo, Egypt; ² Dar Al-Nokhba IVF center, Cairo, Egypt; ³ Department of General and laparoscopic surgery, Cairo University, Cairo, Egypt

11:30 - 11:50

A-0184 ED as a symptom of psychiatric disease
Cobi Reisman
The Netherlands

11:50 - 12:10

A-0211 ED as a symptom of other sexual dysfunctions
Walter Vena
Italy

12:10 - 12:20

A-0043 Prolonged-release Sildenafil in erectile dysfunction: a randomized placebo-controlled comparison with a standard Sildenafil
Andrey Morozov ¹, Svetlana Bogatova ², Valeriia Patrikeeva ², Leonid Spivak ^1
1 Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia; ² Institute for Clinical Medicine, Sechenov University, Moscow, Russia

12:20 - 12:30

A-0027 Living Together, Loving Apart: Health, Sexuality and Relationships in Middle-Aged and Older Men in Europe
Clotilde Sparano ¹, Giammarco Alderotti ², Giulia Rastrelli ³, Giovanni Corona ⁴, Linda Vignozzi ³, Leen Antonio ⁵, Freijo Felipe Casanueva ⁶, Aleksander Giwercman ⁷, Thang S Han ⁸, Ilpo T. Huhtaniemi ⁹, Chiara Lucchi ¹, Terence O'neill ¹⁰, Jolanta Słowikowska-Hilczer ¹¹, Jos Tournoy ¹², Dirk Vanderschueren ⁵, Frederick Wu ¹³, Daniele Vignoli ², Mario Maggi ^1
1 Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence Italy; ² Department of Statistics, Computer Science, Applications, University of Florence, Florence, Italy; ³ Andrology, Women's Endocrinology and Gender Incongruence Unit, Careggi University Hospital, Florence, Italy; ⁴ Endocrinology Unit, Azienda AUSL, Maggiore Hospital, Bologna, Italy; ⁵ Department of Chronic Diseases and Metabolism, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium, Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium; ⁶ Department of Medicine, CIBER de Fisiopatologıa Obesidad y Nutricion, Santiago de Compostela University, Complejo Hospitalario Universitario de Santiago (CHUS) Santiago de Compostela, Spain; ⁷ Department of Translational Medicine, Lund University, Malmö, Sweden; ⁸ Institute of Cardiovascular Research, Royal Holloway, University of London, Egham, Surrey TW20 0EX, UK, Department of Endocrinology, Ashford and St Peter’s NHS Foundation Trust, Guildford Road, Chertsey, Surrey KT16 0PZ, UK; ⁹ Department of Metabolism, Digestion and Reproduction, Institute of Reproductive and Developmental Biology, Imperial College London, London, UK; ¹⁰ NIHR Manchester Biomedical Research Centre, Manchester Academic Health Sciences Centre, Manchester University Foundation NHS Trust, Manchester, United Kingdom; ¹¹ Department of Andrology and Reproductive Endocrinology, Medical University of Łódź, Łódź, Poland; ¹² Department of Geriatrics, University Hospitals Leuven, and Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium; ¹³ Department of Endocrinology, Manchester University NHS Foundation Trust, Manchester, UK

12:30 - 13:00

A-0168 Ion channels in human sperm - a tale of unexplained male infertility and contraception
Timo Strünker
Germany

#A-0001

A-0001 Comparison of demographic and contraceptive patterns in men undergoing vasectomy before and after the COVID-19 pandemic in Barcelona, Spain
Massimiliano Raffo, Josvany Rene Sanchez Curbelo, Maurizio De Rocco Ponce, Luis Malca Caballero, Jose Antonio Arrus Soldi, Ricardo Contreras Garcia, Sebastian Dumas, Gabi Adalid, Eduard Ruiz-Castane, Doron Vantman Luft
Fundacio Puigvert, Barcelona, Spain

#A-0002

A-0002 Assessing vasectomy outcomes and follow-up patterns in relation to contraceptive use: a retrospective analysis
Massimiliano Raffo, Josvany Rene Sanchez Curbelo, Maurizio De Rocco Ponce, Luis Malca Caballero, Jose Antonio Arrus Soldi, Ricardo Contreras Garcia, Sebastian Dumas, Gabi Adalid, Eduard Ruiz-Castane, Doron Vantman Luft
Fundacio Puigvert, Barcelona, Spain

#A-0005

A-0005 Corporoplasty for Peyronie’s disease and congenital penile curvature: real world effectiveness, safety, and patient reported outcomes at a single tertiary-referral center
Massimiliano Raffo, Josvany Rene Sanchez Curbelo, Maurizio De Rocco Ponce, Luis Malca Caballero, Jose Antonio Arrus Soldi, Ricardo Contreras Garcia, Sebastian Dumas, Gabi Adalid, Eduard Ruiz-Castane, Doron Vantman Luft
Fundacio Puigvert, Barcelona, Spain

#A-0009

A-0009 Partnership status and contraceptive method distributions in vasectomy patients with and without children: a single-center analysis
Massimiliano Raffo, Josvany Rene Sanchez Curbelo, Maurizio De Rocco Ponce, Luis Malca Caballero, Jose Antonio Arrus Soldi, Ricardo Contreras Garcia, Sebastian Dumas, Gabi Adalid, Eduard Ruiz-Castane, Doron Vantman Luft
Fundacio Puigvert, Barcelona, Spain

#A-0010

A-0010 Permanent contraception without regret: outcomes of vasectomy in childless men from a tertiary referral center
Massimiliano Raffo, Josvany Rene Sanchez Curbelo, Maurizio De Rocco Ponce, Luis Malca Caballero, Jose Antonio Arrus Soldi, Ricardo Contreras Garcia, Sebastian Dumas, Gabi Adalid, Eduard Ruiz-Castane, Doron Vantman Luft
Fundacio Puigvert, Barcelona, Spain

#A-0011

A-0011 Patient Satisfaction After Penile Prosthesis Implantation in Octogenarians: A Retrospective Comparative Study
Ahmed Al Saeedi ¹, Onder Canguven ^1,2, Khalid AlKubaisi ^1
1 Hamad General Hospital, Urology Department, Doha, Qatar; ² Weill Cornell Medicine: New York, NY, USA

#A-0014

A-0014 Obesity alters sperm function and testicular extracellular vesicle localisation, with frozen tissue limiting vesicle extraction
Sharnah Uys, Erna Marais, Bongekile Skosana
Stellenbosch University, Cape Town, South Africa

#A-0016

A-0016 Serum 17-Hydroxyprogesterone and Intratesticular Testosterone as Predictors of Micro-TESE Outcome in Azoospermic Men
Mohamed Shokr, Mohamed Wael Ragab
Department of Andrology, Kasr El Aini Faculty of Medicine, Cairo University, Egypt

#A-0017

A-0017 Age-specific Prevalence of Male Infertility in Germany: A Comparative Analysis of Infertility criteria based on Self-Reports and Health Insurance Claims Data
Mattia Anfosso ¹, Sabine Kliesch ¹, NAKO collaborators, Hermann M. Behre ², Nicole Rübsamen ³, André Karch ³, Maria Schubert ^1
1 Department of Andrology, Centre of Reproductive Medicine and Andrology (CeRA), University Hospital of Münster, Germany; ² Center for Reproductive Medicine and Andrology, University Hospital Halle, Halle, Germany; ³ Institute of Epidemiology and Social Medicine, Department of Clinical Epidemiology, Münster University

#A-0018

A-0018 mTESE outcome in a patient with Klinefelter syndrome and chromosome Y microdeletion
Dinko Hauptman ¹, Zoran Zimak ¹, Ana Planinić ^2,3, Željko Kaštelan ¹, Davor Ježek ^2,3,4
1 University of Zagreb, School of Medicine, University Hospital Centre Zagreb, Clinic for Urology, Zagreb, Croatia; ² University of Zagreb, School of Medicine, Department of Histology and Embryology, Zagreb, Croatia; ³ University of Zagreb, School of Medicine, Centre of Excellence for Reproductive and Regenerative Medicine, Zagreb, Croatia; ⁴ University of Zagreb, School of Medicine, University Hospital Centre Zagreb, Department of Transfusion Medicine and Transplantation Biology, Zagreb, Croatia

#A-0019

A-0019 Spinal cord injury: does it affect the testis function and sperm retrieval?
Dinko Hauptman ¹, Ana Planinić ^2,3, Zoran Zimak ¹, Željko Kaštelan ¹, Davor Ježek ^2,3,4
1 University of Zagreb, School of Medicine, University Hospital Centre Zagreb, Clinic for Urology, Zagreb, Croatia; ² University of Zagreb, School of Medicine, Department of Histology and Embryology, Zagreb, Croatia; ³ University of Zagreb, School of Medicine, Centre of Excellence for Reproductive and Regenerative Medicine, Zagreb, Croatia; ⁴ University of Zagreb, School of Medicine, University Hospital Centre Zagreb, Department of Transfusion Medicine and Transplantation Biology, Zagreb, Croatia

#A-0020

A-0020 A prospective study on the impact of male BMI on intra-uterine insemination outcome in couples with unexplained or mild male infertility
Mira Sterckx ¹, Alessa Sugihara ², Diane De Neubourg ^3,4, Jolijn Van Cauwenberghe ^1,5
1 Department of Endocrinology, Department of Diabetology and Metabolic Disease, Antwerp University Hospital, Edegem, Belgium; ² Centre for Reproductive Medicine, Algemeen Ziekenhuis Klina, Brasschaat, Belgium; ³ Centre for Reproductive Medicine, Antwerp University Hospital, Edegem, Belgium; ⁴ Department of Reproductive Medicine, Antwerp Surgical Training, Anatomy and Research Centre (ASTARC) Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; ⁵ Laboratory of Experimental Medicine and Paediatrics (LEMP) Faculty of Medicine & Health Sciences, University of Antwerp, Antwerp, Belgium

#A-0021

A-0021 Seminal plasma cfDNA signatures derived from mitochondrial and germ-cell DNA track spermatogenic function in azoospermic men
Marija Lazovska ¹, Dita Gudra ¹, Linda Gailite ¹, Juris Erenpreiss ^1,2
1 Scientific Laboratory of Molecular Genetics, Institute of Oncology and Molecular Genetics, Riga Stradins University, Riga, Latvia; ² iVF Riga Clinic, Riga, Latvia

#A-0023

A-0023 Comparison of sperm functional competence after single and double layer density gradient centrifugation
Satish Kumar Adiga, Huidorm Yaiphaba Meitei, Dhakshanya Predheepan, Shubhashree Uppangala
Department of Reproductive Science, Kasturba Medical College, Manipal-576104, India

#A-0028

A-0028 Patient Perspectives on Klinefelter Syndrome: A Nationwide Survey in Germany on Diagnosis, Treatment, and Care
Caterina Chiminazzo, Jean-Pierre Allam
Andrology Department, Bonn University Hospital, Germany

#A-0029

A-0029 Testicular ultrasound as a screening method for testicular dysfunction in men born with hypospadias: Cross-sectional case-control study
Maaike Kroon ¹, Anne-Françoise Spinoit ¹, Piet Hoebeke ¹, Alexander Springer ², Ursula Tonnhofer ², Stefan Riedl ², Manuela Hiess ³, Ahmed Mahmoud ¹, Erik Van Laecke ¹, Martine Cools ¹, Lloyd J.W. Tack ^1
1 Ghent University Hospital, Ghent, Belgium; ² Medical University of Vienna, Vienna, Austria; ³ Ordensklinikum Linz, Hospital of the Sisters of Charity, Linz, Austria

#A-0031

A-0031 How Reliable is Ultrasonography in Suspected Penile Fracture? Surgical Correlation From A Single-Center Experience
Burak Bilir, Hasan Can Kuvan, Caner Özer, Muhidin Hassan İbrahim, Gökhan Çevik
Trakya University Faculty of Medicine, Urology Department, Edirne, Türkiye

#A-0033

A-0033 The Relationship Between Testosterone and Brain Health and Mental Health in Young Men
Chiara Terzolo, Paul Faulkner
Queen Mary University of London, UK

#A-0034

A-0034 Loss of Y chromosome in male infertility
Valentina Griseta ^1,2, Giorgia Spaggiari ¹, Samantha Sperduti ², Antonio Raffaele Michele Granata ¹, Livio Casarini ², Manuela Simoni ^1,2, Daniele Santi ^1,2
1 Azienda Ospedaliero-Universitaria of Modena, Modena, Italy; ² University of Modena and Reggio Emilia, Modena, Italy

#A-0037

A-0037 New, non-hormonal contraceptive strategies for all genders: The collaborative research project PREVENT
Gina E. Merges ¹, Claudia Tredup ², Jean-Pierre Allam ³, Daniel Merk ⁴, Stefan Knapp ², Hubert Schorle ^1
1 Department of Developmental Pathology, Institute of Pathology, University Hospital Bonn, Bonn, Germany; ² Institute of Pharmaceutical Chemistry and Structural Genomics Consortium, Goethe-University Frankfurt, Frankfurt, Germany; ³ Department of Andrology, University Hospital Bonn, Bonn, Germany; ⁴ Department of Pharmacy, Ludwig-Maximilians-University München, München, Germany

#A-0038

A-0038 Unexplained Male Infertility and Hyperspermia: Integrating Our Clinical Experience with Current Literature Insights
Mehmet Gürcan ¹, Rifat Burak Ergül ¹, Melin İnci Mercan ², İlyas Hakan Ulaş ², Ahmet Halil Sevinç ¹, Taha Uçar ¹, Mazhar Ortaç ¹, Murat Dursun ¹, Ateş Kadıoğlu ^1
1 Istanbul University, Istanbul Faculty of Medicine, Department of Urology, Istanbul, Turkey; ² Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

#A-0039

A-0039 Successful Micro-TESE Following Intratesticular Stromal Vascular Fraction Therapy: A Case Report
İlker Teke, Kağan Kutay Başer, Mevlüt Melih Biçer, Arda Tunç Aydınoğlu, Seyfettin Anıl Tantekin, Mazhar Ortaç, Murat Dursun, Ateş Kadıoğlu
Department of Urology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Türkiye

#A-0040

A-0040 A Case of Non-Obstructive Azoospermia Associated with a Novel X–Autosomal Reciprocal Translocation: 46,XY,t(X;1)(p22.1;p36.1)
Mevlüt Melih Biçer, İlker Teke, Arda Tunç Aydınoğlu, Seyfettin Anıl Tantekin, Mazhar Ortaç, Murat Dursun, Ateş Kadıoğlu
Department of Urology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Türkiye

#A-0041

A-0041 Defining the impact of protamine alterations on sperm epigenetics
Mar Domingo-Lopez, Gina Esther Merges, Hubert Schorle
Department of Developmental Pathology, Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany

#A-0044

A-0044 The effect of Bovhyaluronidase azoximer on bacterial biofilms in the ejaculate of patients with chronic prostatitis and infertility: a randomized controlled trial
Andrey Morozov ¹, Stanislav Vovdenko ¹, Elizaveta Bragina ², Margarita Boldyreva ³, Ofelia Mhitaryan ¹, Dmitry Zubkov ⁴, Valeriia Patrikeeva ⁵, Mikhail Evdokimov ⁶, Magomed Gazimiev ¹, Leonid Spivak ^1
1 Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia; ² A.N. Belozersky Research Institute of Physico-Chemical Biology MSU: Moscow, Russia; ³ NRC Institute of Immunology FMBA of Russia, Moscow, Russia; ⁴ NPO Petrovax Pharm LLC, Moscow, Russia; ⁵ Institute for Clinical Medicine, Sechenov University, Moscow, Russia; ⁶ Semeynaya Poliklinika LLC, Moscow, Russia

#A-0048

A-0048 Molecular Network Signatures of Genome Instability in Azoospermia and Oligoasthenoteratozoospermia
Baiba Cielēna ¹, Agrita Puzuka ^1,2, Linda Gailīte ¹, Dita Gudrā ¹, Ninel Miriam Vainselbaum ³, Jānis Kristaps Vasiļonoks ⁴, Elvita Penka ⁴, Rūta Romanosa ⁴, Violeta Fodina ⁴, Juris Ērenpreiss ^1,4
1 Institute of Oncology and Molecular Genetics, Riga Stradins University, Riga, Latvia; ² Department of Biology and Microbiology, Riga Stradins University, Riga, Latvia; ³ Latvian Biomedical Research and Study Center, Riga, Latvia; ⁴ iVF Riga Clinic, Riga, Latvia

#A-0051

A-0051 Transcription profiles of mitochondrial dynamics markers are altered in men with teratozoospermia
Tamara D Bogdanovic, Isidora M Keselj, Tamara M Tomanic, Sava M Radovic Pletikosic, Tatjana S Kostic, Silvana A Andric
Laboratory for Reproductive Endocrinology and Signaling, Laboratory for Chronobiology and Aging, CeRES, DBE, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia

#A-0052

A-0052 Long-term effects of chemotherapy on sperm DNA fragmentation and sperm-borne miRNAs in testicular cancer survivors
Anna Chiara Conflitti, Alessandra Buonacquisto, Gaia Cicolani, Martina Tartacca, Federica Quaranta, Luisa Caponecchia, Maria Rosaria Abate, Enrico Delli Paoli, Silvia Di Chiano, Sara Pitton, Francesco Lombardo, Donatella Paoli
Laboratory of Seminology and Sperm Bank “L. Gandini” - Department of Experimental Medicine, University of Rome "Sapienza", 00161, Rome, Italy

#A-0053

A-0053 Exome evaluation by Next Generation Sequencing in sibling pairs with testicular cancer
Anna Chiara Conflitti ¹, Gaia Cicolani ¹, Alessandra Buonacquisto ¹, Federica Quaranta ¹, Martina Tartacca ¹, Enrico Delli Paoli ¹, Silvia Di Chiano ¹, Roberto Abdel Malek ¹, Vittorio Di Pietro ¹, Irene Bottillo ², Francesco Lombardo ¹, Donatella Paoli ^1
1 Laboratory of Seminology and Sperm Bank “L. Gandini” - Department of Experimental Medicine, Sapienza University, Rome, Italy; ² Division of Medical Genetics, Department of Experimental Medicine, San Camillo-Forlanini Hospital, Sapienza University, Rome, Italy

#A-0054

A-0054 Machine Learning and Deep Learning Models for Predicting Testicular Sperm Retrieval in Men with Azoospermia: Development of a Clinical Decision Support Tool
Islam M Abdelrahman ¹, Haitham El-Hussieny ², Abdelrahman A Aburahma ¹, Sameh Fayek Gamaleldin ¹, Mohamed Wael Ragab ^1,3
1 Department of Andrology, Cairo University, Cairo, Egypt; ² Department of Mechatronics and Robotics Engineering, Egypt-Japan University of Science and Technology (E-JUST) Alexandria, Egypt; ³ Dar Al-Nokhba IVF Center, Cairo, Egypt

#A-0055

A-0055 The association between human sperm motility pattern in polyvinylpyrrolidone (PVP) medium and embryological outcome
Amandeep Kaur ¹, Safna Muthirakala Ibrahim ¹, Samruddhi Musalgaonkar ¹, Huidrom Yaiphaba Meitei ¹, Dhakshanya Predheepan ¹, Stefan Schlatt ², Satish Kumar Adiga ^1
1 Centre of Excellence in Clinical Embryology, Department of Reproductive Science, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India; ² Centre of Reproductive Medicine and Andrology (CeRA) University of Münster, Münster, Germany

#A-0056

A-0056 Reproductive implications of Y chromosome microdeletions
Malene Asp Bock Mejdahl ^1,2,3, Iben Bache ³, Anders Juul ^1,2,4, Lise Aksglaede ^1,2, Kristian Almstrup ^1,2,5
1 Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Denmark; ² International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health, Copenhagen, Denmark; ³ Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet, Denmark; ⁴ Department of Clinical Medicine, University of Copenhagen, Denmark; ⁵ Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark

#A-0058

A-0058 Selected markers of oxidative stress in semen of men with low sperm motility
Danuta Paczejko ¹, Kamil Gill ¹, Monika Frączek ², Maciej Kurpisz ², Małgorzata Piasecka ^1
1 Department of Histology and Developmental Biology, Faculty of Health Sciences, Pomeranian Medical University, Szczecin, Poland; ² Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland

#A-0059

A-0059 Short-term sexual abstinence as a meaningful and easily modifiable factor affecting sperm DNA integrity
Kamil Gill ¹, Mariusz Łukaszuk ², Tomasz Machałowski ³, Małgorzata Piasecka ^1
1 Department of Histology and Developmental Biology, Faculty of Health Sciences, Pomeranian Medical University, Szczecin, Poland; ² Novique—Aesthetic and Anti-Aging Medicine Clinic, Gdańsk, Poland; ³ Department of Perinatology, Obstetrics and Gynaecology, Faculty of Medicine, Pomeranian Medical University in Szczecin, Szczecin, Poland

#A-0060

A-0060 Age-related decline in testicular volume: a population-based UK Biobank study
Vanessa Schwarzkopf ¹, Lynn Ogoniak ^1,2, Philipp Beeken ¹, Gunnar P. Kordes ¹, Alexander S. Busch ^1
1 Department of General Pediatrics, University of Münster, Germany; ² Institute of Medical Informatics, University of Münster, Germany

#A-0061

A-0061 Plasma proteomics reveals a circulating signature of quantitative spermatogenesis
Vanessa Schwarzkopf ¹, Lynn Ogoniak ^1,2, Philipp Beeken ¹, Gunnar P. Kordes ¹, Alexander S. Busch ^1
1 Department of General Pediatrics, University of Münster, Germany; ² Institute of Medical Informatics, University of Münster, Germany

#A-0062

A-0062 Fertility preservation in prepubertal patients: validation of a protocol for testicular tissue cryopreservation
Ragosta Maria Emanuela ¹, Guarnieri Giulia ², Traini Giulia ¹, Tamburrino Lara ³, Mencarelli Flavia ², Baldi Elisabetta ², Morelli Annamaria ², Vignozzi Linda ^1,3, Marchiani Sara ^1,3
1 Dept of Experimental Clinical and Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy; ² Dept of Experimental and Clinical Medicine, University of Florence, Florence, Italy; ³ Andrology, Women's Endocrinology and Gender Incongruence Unit, Center for Prevention, Diagnosis and Treatment of Infertility, Careggi University Hospital, Florence, Italy

#A-0063

A-0063 Magnetic Activated Cell Sorting (MACS) and molecular profile analysis of male gamete
Federica Quaranta ¹, Gaia Cicolani ¹, Anna Chiara Conflitti ¹, Alessandra Buonacquisto ¹, Martina Taracca ¹, Luisa Caponecchia ¹, Sara Pitton ¹, Silvia Di Chiano ¹, Enrico Delli Paoli ¹, Francesco Pallotti ¹, Donatella Paoli ¹, Francesco Lombardo ^1
1 Laboratory of Seminology and Sperm Bank “Loredana Gandini”, Department of Experimental Medicine, “Sapienza” University of Rome, 00161 Rome, Italy; ² Department of Medicine, University of Enna, Kore, Italy

#A-0064

A-0064 Obesity and Assisted Reproduction: molecular study of male gametes
Gaia Cicolani ¹, Anna Chiara Conflitti ¹, Alessandra Buonacquisto ¹, Federica Quaranta ¹, Martina Tartacca ¹, Silvia Di Chiano ¹, Enrico Delli Paoli ¹, Antonella Linari ², Valerio Pisaturo ², Ludovico Muzii ², Francesco Pallotti ³, Donatella Paoli ¹, Francesco Lombardo ^1
1 Laboratory of Seminology-Sperm Bank 'Loredana Gandini', Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy; ² Department of Maternal Infantile and Urological Sciences, 'Sapienza' University of Rome, Rome, Italy; ³ Department of Medicine and Surgery, 'Kore' University of Enna, Enna, Italy

#A-0065

A-0065 Exploring lyophilization as an alternative strategy for human sperm biobanking
Traini Giulia ¹, Ragosta Maria Emanuela ¹, Tamburrino Lara ², Elisabetta Baldi ³, Vignozzi Linda ^1,2, Marchiani Sara ^1,2
1 Dept. of Experimental Clinical and Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy; ² Andrology, Women's Endocrinology and Gender Incongruence Unit, Center for Prevention, Diagnosis and Treatment of Infertility, Careggi University Hospital, Florence, Italy; ³ Dept. of Experimental and Clinical Medicine, University of Florence, Florence, Italy

#A-0066

A-0066 Optimizing sperm cryopreservation: evaluating the most effective sample preparation method
Traini Giulia ¹, Ragosta Maria Emanuela ¹, Tamburrino Lara ², Vignozzi Linda ^1,2, Baldi Elisabetta ³, Marchiani Sara ^1,2
1 Dept. of Experimental Clinical and Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy; ² Andrology, Women's Endocrinology and Gender Incongruence Unit, Center for Prevention, Diagnosis and Treatment of Infertility, Careggi University Hospital, Florence, Italy; ³ Dept. of Experimental and Clinical Medicine, University of Florence, Florence, Italy

#A-0067

A-0067 Developmental Impact of Testosterone on the Brain–Testis Axis in Rats with Hypogonadism: Preliminary Results
Merve Acikel Elmas ^1,8, Sezin Cevik ², Gizem Kosif ², Nursima Mutlu ³, Samed Ozer ⁴, Gokcen Ozgun ², Erdi Sozen ⁵, Filiz Onat ⁶, Emel Baloglu ⁷, Serap Arbak ^8
1 Department of Histology and Embryology, School of Medicine, Marmara University, Istanbul, Türkiye; ² Department of Histology and Embrology, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Türkiye; ³ Department of Neuroscience, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Türkiye; ⁴ Experimental Animals Research Center, Acibadem Mehmet Ali Aydinlar University, Istanbul, Türkiye; ⁵ Department of Biochemistry, School of Medicine, Marmara University, Istanbul, Türkiye; ⁶ Department of Medical Pharmacology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Türkiye; ⁷ Department of Medical Pharmacology, School of Medicine, Istanbul Medeniyet University, Istanbul, Türkiye; ⁸ Department of Histology and Embryology, School of Medicine, Acibadem University, Istanbul, Türkiye

#A-0072

A-0072 Early detection of relapsing testicular germ cell tumours using miR-371a-3p and miR-373-3p
Nina Mørup* ^1,2, Helle Margit Albrechtsen* ^1,2, Roberta Palazzo ^1,2, Gedske Daugaard ³, Kristian Almstrup ^1,2,4
1 Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Denmark; ² International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health, Copenhagen, Denmark; ³ Department of Oncology, Copenhagen University Hospital – Rigshospitalet, Denmark; ⁴ Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark

#A-0073

A-0073 Metabolic parameters as predictive factors for a full-term pregnancy in males of infertile couples: preliminary data from patients attending a new service for infertility treatment
Sarah Cipriani ^1,2,3,4, Sara Marchiani ^1,2,3, Francesca Frizza ^2,3, Mattia Annunziato ¹, Noemi Fralassi ^1,2,3,4, Michela Cirillo ⁵, Laura Di Renzo ⁶, Stefania Magnolfi ⁴, Giulia Rastrelli ^1,2,3, Mario Maggi ^1,7, Linda Vignozzi ^1,2,3
1 Department of Experimental, Clinical and Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy; ² Andrology and Gender Endocrinology Unit, University Hospital Careggi, Florence, Italy; ³ Center for Prevention, Diagnosis and Treatment of Infertility, University Hospital Careggi, Florence, Italy; ⁴ Aware Fertility Unit, AUSL Toscana Centro, Florence, Italy; ⁵ Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; ⁶ Section of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, Tor Vergata University of Rome, Rome, Italy; ⁷ Endocrinology Unit, University Hospital Careggi, Florence, Italy

#A-0075

A-0075 The role of the radiologist in the evaluation of male infertility: recommendations of the European Society of Urogenital Radiology Scrotal and Penile Imaging Working Group (ESUR-SPIWG) for scrotal imaging
Francesco Lotti ^1,2, Michal Studniarek ³, Cristina Balasa ⁴, Jane Belfield ⁵, Pieter De Visschere ⁶, Simon Freeman ⁷, Oliwia Kozak ³, Karolina Markiet ³, Subramaniyan Ramanathan ^8,9, Jonathan Richenberg ¹⁰, Mustafa Secil ¹¹, Katarzyna Skrobisz ³, Athina Tsili ¹², Michele Bertolotto ¹³, Laurence Rocher ^14
1 Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy; ² Andrology and Gender Endocrinology Unit, University Hospital Careggi (AOUC), Florence, Italy; ³ Department of Radiology, Medical University of Gdańsk, Gdańsk, Poland; ⁴ Hôpitaux Paris Sud, service de radiologie diagnostique et interventionnelle, site Bicêtre, 94270 Le Kremlin Bicêtre, France; ⁵ Department of Radiology, Royal Liverpool University Hospital, Liverpool, UK ; ⁶ Department of Radiology and Nuclear Medicine, Ghent University Hospital, Ghent, Belgium ; ⁷ University Hospitals Plymouth NHS Trust, Derriford Hospital, Derriford Road, Crownhill, Plymouth, Devon, PL6 8DH, UK ; ⁸ Department of Radiology, Al-Wakra Hospital, Hamad Medical Corporation, PO Box 82228, Doha, Qatar ; ⁹ Department of Radiology, Weill Cornell Medical College, Doha, Qatar ;¹⁰ Department of Imaging, Brighton and Sussex University Hospitals NHS Trust and Brighton and Sussex Medical School, Brighton, UK ; ¹¹ Department of Radiology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey ; ¹² Department of Clinical Radiology, School of Health Sciences, Faculty of Medicine, University of Ioannina, 45110 Ioannina, Greece ; ¹³ Department of Radiology, University of Trieste, Ospedale di Cattinara, Trieste, Italy ; ¹⁴ Antoine Béclère Hospital, APHP, Biomaps, Paris Saclay University, 157 rue de la Porte de Trivaux, 92140 Clamart

#A-0077

A-0077 Semen quality in acute leukaemia patients: a retrospective study
Silvia Di Chiano ¹, Alessandra Buonacquisto ¹, Maria Ilaria Del Principe ^3,4,5, Enrico Delli Paoli ¹, Francesco Pallotti ², Serena Bianchini ¹, Elisa Buzzatti ⁶, Luisa Caponecchia ¹, Sabina Chiaretti ⁷, Gaia Cicolani ¹, Anna Chiara Conflitti ¹, Ludovica Fucci ⁷, Deborah Kasmi ⁷, Clara Minotti ⁷, Federica Quaranta ¹, Ilaria Tiravanti ⁶, Adriano Venditti ^6,8, Francesco Lombardo ¹, Donatella Paoli ^1
1 Laboratory of Seminology 'Loredana Gandini' Sperm Bank, Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy; ² Department of Medicine and Surgery, University of Enna 'Kore', Enna, Italy; ³ Department of Hematology, University of Rome Tor Vergata, Rome, Italy; ⁴ UOSD Patologie Mieloproliferative, Policlinico Tor Vergata, Rome, Italy; ⁵ Department Biomedicine and Prevention, Faculty of Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy; ⁶ Department of Hematology, University of Rome Tor Vergata, Rome, Italy; ⁷ Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy; ⁸ UOSD Patologie Mieloproliferative, Policlinico Tor Vergata, Rome, Italy

#A-0078

A-0078 Gender-Affirming Hormone Therapy: Impact on Fertility and Testicular Function
Enrico Delli Paoli ¹, Silvia Di Chiano ¹, Anna Chiara Conflitti ¹, Roberto Abdel Malek ¹, Vittorio Di Pietro ¹, Sara Pitton ¹, Federica Quaranta ¹, Gaia Cicolani ¹, MarttinaTartacca ¹, Alessandra Buonacquisto ¹, Francesco Pallotti ², Donatella Paoli ¹, Francesco lombardo ^1
1 Laboratory of Seminology 'Loredana Gandini' Sperm Bank, Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy; ² Department of Medicine and Surgery, University of Enna 'Kore', Enna, Italy

#A-0081

A-0081 Human primary granulosa cells did not replace Sertoli cells in enhancing Leydig cell response to gonadotropins
Giada Mercanile ^1,2, Clara Lazzaretti ¹, Samantha Sperduti ^1,3, Carmela Perri ^1,4, Manuela Simoni ^1,3,5, Livio Casarini ^1,3
1 Unit of Endocrinology. Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; ² Unit of Dermatology, Department of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia, Modena, Italy; ³ Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy; ⁴ International PhD School in Clinical and Experimental Medicine (CEM) University of Modena and Reggio Emilia, Modena, Italy; ⁵ Azienda Ospedaliero-Universitaria di Modena, Department of Medical Specialties, Modena, Italy

#A-0082

A-0082 Preparations of recombinant follicle-stimulating hormone (FSH) alfa and delta induce different intracellular signals in vitro
Samantha Sperduti ^1,2, Clara Lazzaretti ¹, Giada Mercanile ^1,3, Carmela Perri ^1,4, Elisa Mascolo ¹, Manuela Simoni ^1,2,5, Livio Casarini ^1,2
1 University of Modena and Reggio Emilia, Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Modena, Italy; ² Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy; ³ Department of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia, Modena, Italy; ⁴ International PhD School in Clinical and Experimental Medicine (CEM) University of Modena and Reggio Emilia, Modena, Italy; ⁵ Azienda Ospedaliero-Universitaria di Modena, Department of Medical Specialties, Modena, Italy

#A-0083

A-0083 Validation of the Turkish Version of the ANDROTEST for Detecting Male Hypogonadism in Patients with Sexual Dysfunction
Abdullah Akdag, Enes Aktas, Akif Erbin, Batu Akalin, Halil Lutfi Canat
Department of Urology, Basaksehir Cam Sakura City Hospital, Istanbul, Turkey

#A-0084

A-0084 Shear Wave Elastography of the Testis in a Mexican Series of 105 Patients: Technical Standardization, Reproducibility, and Quantitative Characterization
Moises Abraham Adel Domínguez, Andrés Mora Topete
Centro de Uro Andrología, Guadalajara, Jalisco, México

#A-0087

A-0087 The role of the radiologist in the evaluation of male infertility: recommendations of the European Society of Urogenital Radiology Scrotal and Penile Imaging Working Group (ESUR-SPIWG) for prostate-vesicular imaging
Francesco Lotti ^1,2, Michal Studniarek ³, Cristina Balasa ⁴, Jane Belfield ⁵, Pieter De Visschere ⁶, Simon Freeman ⁷, Oliwia Kozak ³, Karolina Markiet ³, Subramaniyan Ramanathan ^8,9, Jonathan Richenberg ¹⁰, Mustafa Secil ¹¹, Katarzyna Skrobisz ³, Athina Tsili ¹², Michele Bertolotto ¹³, Laurence Rocher ^14
1 Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy; ² Andrology and Gender Endocrinology Unit, University Hospital Careggi (AOUC), Florence, Italy; ³ Department of Radiology, Medical University of Gdańsk, Gdańsk, Poland; ⁴ Hôpitaux Paris Sud, service de radiologie diagnostique et interventionnelle, site Bicêtre, 94270 Le Kremlin Bicêtre, France; ⁵ Department of Radiology, Royal Liverpool University Hospital, Liverpool, UK ; ⁶ Department of Radiology and Nuclear Medicine, Ghent University Hospital, Ghent, Belgium ; ⁷ University Hospitals Plymouth NHS Trust, Derriford Hospital, Derriford Road, Crownhill, Plymouth, Devon, PL6 8DH, UK ; ⁸ Department of Radiology, Al-Wakra Hospital, Hamad Medical Corporation, PO Box 82228, Doha, Qatar ; ⁹ Department of Radiology, Weill Cornell Medical College, Doha, Qatar ;¹⁰ Department of Imaging, Brighton and Sussex University Hospitals NHS Trust and Brighton and Sussex Medical School, Brighton, UK ; ¹¹ Department of Radiology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey ; ¹² Department of Clinical Radiology, School of Health Sciences, Faculty of Medicine, University of Ioannina, 45110 Ioannina, Greece ; ¹³ Department of Radiology, University of Trieste, Ospedale di Cattinara, Trieste, Italy ; ¹⁴ Antoine Béclère Hospital, APHP, Biomaps, Paris Saclay University, 157 rue de la Porte de Trivaux, 92140 Clamart

#A-0088

A-0088 Hypogonadism and sexual function in men affected by adrenocortical carcinoma under mitotane therapy
Letizia Canu ^1,2,3,4, Clotilde Sparano ^1,2, Lara Naletto ¹, Giuseppina De Filpo ¹, Giulia Cantini ^1,3,4, Elena Rapizzi ^3,4,5, Serena Martinelli ^1,3,4, Tonino Ercolino ^2,3,4, Francesca Cioppi ⁵, Alessandro Fantoni ¹, Lorenzo Zanatta ^1,2, Alessandro Terreni ⁶, Massimo Mannelli ^1,3,4, Michaela Luconi ^1,3,4, Mario Maggi ^1,2,3,4, Francesco Lotti ^7,8
1 Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy; ² Endocrinology Unit, Careggi University Hospital (AOUC), Florence, Italy; ³ Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy; ⁴ ENS@T Center of Excellence, Florence, Italy; ⁵ Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; ⁶ Department of Laboratory, Careggi University Hospital (AOUC), Florence, Italy; ⁷ Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy; ⁸ Andrology and Gender Endocrinology Unit, University Hospital Careggi (AOUC), Florence, Italy

#A-0090

A-0090 Prediction of clinical pregnancy outcomes using VideoMAE pre-training and multiple instance learning on sperm videos
Jin-Chuan Liu ^1,2, Jianfeng Wang ³, Fu Shi ¹, Yue Chen ¹, Jiangxia Shi ¹, Jing Zhao ¹, Suxia Lin ¹, Yu Li ¹, William Yeung ¹, Yong-Gang Duan ^1
1 Shenzhen Key Laboratory of Fertility Regulation, Center of Assisted Reproduction and Embryology, The University of Hong Kong - Shenzhen Hospital, Shenzhen, China; ² Department of Obstetrics and Gynecology, the University of Hong Kong, Pokfulam Road, Hong Kong, China; ³ Basecare Medical Device Co., Ltd., Suzhou, China

#A-0091

A-0091 A novel marker for sperm quality - semen antioxidant capacity is associated with ICSI outcomes
Violeta Fodina ¹, Anna Dorondo ¹, Julija Tarasova ¹, Andris Grunskis ¹, Ruta Romanosa ¹, Dace Enkure ¹, Anna Zdanovica ¹, Diana Vevere ¹, Juris Erenpreiss ^1,2
1 iVF Riga Clinic, Latvia, Riga, Latvia; ² Riga Stradins University, Riga, Latvia

#A-0092

A-0092 Metabolic dysfunction–associated steatotic liver disease and testosterone serum levels: converging evidence from real-world observational data and meta-analysis
Martina Colli ^1,2, Leonardo Dalla Valentina ¹, Cristina Felicani ⁴, Filippo Gabrielli ^4,5, Simonetta Lugari ⁴, Antonio Granata ^2,3, Manuela Simoni ^1,2, Paolo Ventura ^4,5, Fabio Nascimbeni ^4,5, Giorgia Spaggiari ^1,2,3, Daniele Santi ^1,2,3
1 University of Modena and Reggio Emilia, Department of Biomedical, Metabolic and Neural Sciences, Modena, Italy; ² Azienda Ospedaliero-Universitaria of Modena, Unit of Endocrinology, Department of Medical Specialties, Modena, Italy; ³ Azienda Ospedaliero-Universitaria of Modena, Unity of Andrology and Sexual Medicine of the Unit of Endocrinology, Department of Medical Specialties, Modena, Italy; ⁴ Azienda Ospedaliero-Universitaria of Modena, Unit of Internal Medicine and Metabolism, Modena, Italy; ⁵ University of Modena and Reggio Emilia, Department of Maternal-Infantile and Adult Medical and Surgical Sciences, Modena, Italy

#A-0094

A-0094 Advanced Sperm Selection in Previously failed ICSI : Magnetic-Activated Cell Sorting and Microfluidic Sperm Chips Approaches
Mina Saad ^1,2, Emad El-Zayat ³, Nouran Reda ^2,3, Waleed Hamed ², Mohamed Wael Ragab ^1,2
1 Department of Andrology, Cairo University, Cairo, Egypt; ² Dar Al-Nokhba IVF center, Cairo, Egypt; ³ Department of Biotechnology, Faculty of Science, Cairo University, Egypt

#A-0097

A-0097 Metabolic Syndrome in Men from Infertile Couples: ReproUnion Biobank and Infertility Cohort (RUBIC)
Maria Dahlberg ¹, Alexandra Kondic ¹, Karin Odlén ¹, Sofie Fagerström ¹, Angel Elenkov ¹, Anders Juul ², Sandra Søgaard Tøttenborg ³, Margareta Kitlinski ¹, Aleksander Giwercman ^1
1 Department of Translational Medicine, Lund University, Malmö, Sweden; ² Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark; ³ Department of Environmental and Occupational Medicine, Bispebjerg and Fredriksberg Hospital, Copenhagen, Denmark

#A-0102

A-0102 Clinical significance of the infiltration of leukocytes into seminal plasma and the downstream effects on sperm cells
Vishalini Pillay, Khomotso Mathabatha, Lenine Liebenberg, Bongekile Skosana
Stellenbosch University, Cape Town, South Africa

#A-0103

A-0103 Nrf2 evaluation in human semen and its relationship with F2 -Isoprostanes as marker of lipid peroxidation
Laura Liguori ¹, Elena Leoni ¹, Caterina Marcucci ², Giulia Collodel ¹, Cinzia Signorini ¹, Elena Moretti ^1
1 Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy; ² Chianciano Salute Clinic, Chianciano Terme, Siena, Italy

#A-0104

A-0104 A case report of diagnostic odyssey of a 46,XY difference of sex development: one of the many faces of the Reifenstein Syndrome
Ion Castravet ¹, Aurore Garde ², Lucie Rey ¹, Morgan Moulin ³, Margot Machado ¹, Pauline Charpentier ¹, Laurence Faivre ², Mathilde Cavalieri ¹, Julie Barberet ^1
1 Fertility Institute, Dijon University Hospital Centre, France; ² Clinical Genetics Department, Dijon University Hospital Centre, France; ³ Urology Department, Dijon University Hospital Centre, France

#A-0105

A-0105 Protective Effects of Neuropeptide W in Testicular Ischemia-Reperfusion Injury in Rats
Yasemin Cesur ¹, Leyla Semiha Şen ², M Kutay Köroğlu ¹, Alperen Akbaba ³, Meral Yüksel ⁴, Berrak Yeğen ³, Feriha Ercan ^1
1 Marmara University, School of Medicine, Department of Histology & Embryology, Istanbul, Turkey; ² Marmara University, Pendik Training and Research Hospital, Clinic of General Surgery, Istanbul, Turkey; ³ Marmara University, School of Medicine, Department of Physiology, Istanbul, Turkey; ⁴ Marmara University, Vocational School of Health Services, Department of Medical Services and Techniques, Istanbul, Turkey

#A-0108

A-0108 A Nomogram for Predicting Biochemical Hypogonadism in Men With Chronic Spinal Cord Injury
Luca Spagnolo, Daniele Tienforti, Elisa Cocci, Carlo Pisanò, Matteo Civilla, Arcangelo Barbonetti
Andrology Unit, Hospital S. Salvatore, Department of Medical, Health, Life and Ambiental Sciences, University of L'Aquila, L'Aquila, Italy

#A-0113

A-0113 Circadian Desynchrony Impairs Mitochondrial Bioenergetics During Spermiogenesis and Compromises Sperm Function
Alisa Becin, Silvana Andric, Tatjana Kostic
Faculty of Sciences, University of Novi Sad, Serbia

#A-0114

A-0114 Low Testosterone and Sperm Quality Alterations: A Prospective Study of Sperm DNA Fragmentation and Chromatin Condensation in Infertile Men
Asmaa Serbouti ¹, Kenza Berrada ¹, Samy Housbane ², Noureddine Louanjli ³, Rachid Aboutaieb ^1,4
1 Laboratory of Sexual and Reproductive Health, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco; ² Department of Medical Informatics, Faculty of Medicine and Pharmacy, Hassan II University Casablanca, Casablanca, Morocco; ³ Labomac IVF Center and Clinical Laboratory Medicine, Casablanca, Morocco; ⁴ Department of Urology, CHU Ibn Rochd, Casablanca, Morocco

#A-0115

A-0115 Congenital adrenal hyperplasia with bilateral testicular adrenal rest tumors and azoospermia: a case report and literature review
Peng Ge, He Zhang, Junqi Wang
Department of Urology, The Affiliated Hospital of Xuzhou Medical University, 221002 Xuzhou, Jiangsu, China

#A-0116

A-0116 Advances in biomarker research in premature ejaculation
Peng Ge, Jinzhi Wang, Junqi Wang, Hailong Li
Department of Urology, The Affiliated Hospital of Xuzhou Medical University, 221002 Xuzhou, Jiangsu, China

#A-0117

A-0117 Evaluation of oxidative stress and its impact on sperm DNA fragmentation and semen parameters in infertile men
Kenza Berrada ¹, Yasmine Touhamia ²*, Asmaa serbouti ¹, Rym Saidi ³, Abderrahmane Aamiri ², Fatima Ez-Zahra Ousaid ², Samy, Housbane ⁴, Noureddine Louanjli ⁵, Rachid Aboutaieb ^1
1 Laboratory of Sexual and Reproductive Health, Faculty of Medicine and Pharmacy, Hassan II University of, Casablanca, Casablanca, Morocco; ² Health, Environment and Biotechnology Laboratory, Faculty of Sciences Ain Chock, Hassan II University, Casablanca, Morocco; ³ AgroBioSciences Program, College of Agriculture and Environmental Sciences (CAES) Mohammed VI; Polytechnic University; (UM6P) Ben Guerir, Morocco; ⁴ Department of Medical Informatics, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca; Casablanca, Morocco; ⁵ Labomac Laboratory of Medical Analysis and Reproductive Biology, Casablanca, Morocco; ⁶ Department of Urology, Ibn Rochd University Hospital Center, Casablanca, Morocco

#A-0120

A-0120 Postoperative Hormonal Changes After Surgical Sperm Retrieval in Men with Infertility
Mohamed Arafa ^1,2,3, Khalid AlKubaisi ¹, Ahmed AlSaeedi ¹, Kareim Khalafalla ^1,4, Ahmad Almalki ^1,4, Sami AlSaid ^1,2, Nadir Fadol ¹, Ahmad Majzoub ^1,2, Haitham Elbardisi ^1,2,4
1 Urology Department, Hamad Medical Corporation, Doha, Qatar; ² Urology Department, Weill Cornell Medicine-Qatar, Doha, Qatar; ³ Andrology Department, Cairo University, Doha, Qatar; ⁴ Urology Department, Qatar University, Doha, Qatar

#A-0121

A-0121 Can Serum FSH Predict Surgical Sperm Retrieval Success? A Retrospective Analysis
Haitham Elbardisi ^1,2,3, Khalid Alkubaisi ¹, Nadir Fadol ¹, Ahmad Almalki ^1,3, Kareim Khalafalla ^1,3, Sami AlSaid ^1,2, Ahmed AlSaeedi ¹, Ahmad Majzoub ^1,2, Mohamed Arafa ^1,2,4
1 Urology Department, Hamad Medical Corporation, Doha, Qatar; ² Urology Department, Weill Cornell Medicine-Qatar, Doha, Qatar; ³ Urology Department, Qatar University, Doha, Qatar; ⁴ Andrology Department, Cairo University, Doha, Qatar

#A-0123

A-0123 ICSI Outcomes in Absolute Asthenozoospermia: A Comparison of Ejaculated and Testicular Sperm
Ahmad Majzoub ^1,2, Kareim Khalafalla ^1,3, Nadir Fadol ¹, Ahmad Almalki ^1,3, Sami AlSaid ^1,2, Khalid Alkubaisi ^1,3, Ahmed AlSaeedi ¹, Haitham Elbardisi ^1,2,3, Mohamed Arafa ^1,2,4
1 Urology Department, Hamad Medical Corporation, Doha, Qatar; ² Urology Department, Weill Cornell Medicine-Qatar, Doha, Qatar; ³ Urology Department, Qatar University, Doha, Qatar; ⁴ Andrology Department, Cairo University, Doha, Qatar

#A-0124

A-0124 ICSI Outcomes Across Different Levels of Normal Sperm Morphology: A Retrospective Analysis
Haitham Elbardisi ^1,2,3, Ahmad Almalki ^1,3, Ahmed Alsaeedi ¹, Kareim Khalafalla ^1,3, Khalid AlKubaisi ¹, Sami AlSaid ^1,2, Nadir Fadol ¹, Mohamed Arafa ^1,2,4, Ahmad Majzoub ^1,2
1 Urology Department, Hamad Medical Corporation, Doha, Qatar; ² Urology Department, Weill Cornell Medicine-Qatar, Doha, Qatar; ³ Urology Department, Qatar University, Doha, Qatar; ⁴ Andrology Department, Cairo University, Doha, Qatar

#A-0125

A-0125 Low free testosterone is independently associated with long-term mortality in men with chronic spinal cord injury
Elisa Cocci, Luca Spagnolo, Daniele Tienforti, Carlo Pisano', Matteo Civilla, Arcangelo Barbonetti
Andrology Unit, Hospital S. Salvatore, Department of Medical, Health, Life and Ambiental Sciences, University of L'Aquila, L'Aquila, Italy

#A-0127

A-0127 Tirzepatide-induced testosterone recovery in obese men: clinical evidence supporting an adipose–liver–gonadal axis
Valentina Paternò ¹, Giulio Geraci ^1,2, Simone Argento ¹, Tommaso Piticchio ², Rosario Le Moli ², Francesco Pallotti ^1,2,3
1 Internal Medicine Unit, Hospital Umberto I, Enna, Italy; ² University of Enna "Kore", Department of Medicine and Surgery, Enna, Italy; ³ Diabetology and Endocrinology Unit, Hospital Umberto I, Enna, Italy

#A-0128

A-0128 Adiposity distribution predicts testosterone recovery during tirzepatide therapy in obese men
Valentina Paternò ¹, Giulio Geraci ^1,2, Simone Argento ¹, Tommaso Piticchio ², Rosario Le Moli ², Francesco Pallotti ^1,2,3
1 Internal Medicine Unit, Hospital Umberto I, Enna, Italy; ² University of Enna "Kore", Department of Medicine and Surgery, Enna, Italy; ³ Diabetology and Endocrinology Unit, Hospital Umberto I, Enna, Italy

#A-0129

A-0129 Gut microbiota enterotypes in aging man with benign prostatic hyperplasia (BPH)
Olimpia Sipak ¹, Weronika Ratajczak-Zacharko ², Karolina Skonieczna-Żydecka ³, Maria Laszczyńska ⁴, Anna Lubkowska ^2
1 Department of Obstetrics and Pathology of Pregnancy, Faculty of Life Science, Pomeranian Medical University, Szczecin, Poland; ² Department of Functional Diagnostics and Physical Medicine, Faculty of Life Science, Pomeranian Medical University, Szczecin, Poland; ³ Department of Biochemical Sciences, Faculty of Life Science, Pomeranian Medical University, Szczecin, Poland; ⁴ Department of Nursing, State University of Applied Sciences, Koszalin, Poland

#A-0131

A-0131 Impact of Age on Outcomes of Microsurgical Subinguinal Varicocelectomy in Infertile Men
Aleksei Ryzhkov ¹, Svetlana Sokolova ², Igor Shormanov ^1
1 Yaroslavl State Medical University, Yaroslavl, Russia; ² Mother and Child Clinic, Yaroslavl, Russia

#A-0133

A-0133 Seminal Plasma Oxylipins and NMR Metabolites in Normal and Impaired Spermatogenesis
Artem Pustovid ¹, Vitalik Bezuglov ^1,2, Dmitry Chistyakov ^2,3, Sabina Khayat ⁴, Marina Andreeva ⁴, Maria Shtaut ⁴, Olga Solovova ⁴, Sergey Goriainov ³, Vasily Ivlev ³, Vasiliy Vasilev ³, Vyacheslav Chernykh ⁴, Oleg Sergeyev ^1,2,4
1 Skolkovo Institute of Science and Technology, Moscow, Russia; ² Lomonosov Moscow State University, Moscow, Russia; ³ Institute of Pharmacy and Biotechnology (IPhB) Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia; ⁴ Research Centre for Medical Genetics, Moscow, Russia

#A-0135

A-0135 Volumetric response of hypoechoic testicular micronodules in men with primary gonadal failure treated with testosterone therapy
Franz Sesti ¹ Davide Ferrari ², Marta Tenuta ², Francesco Carlomagno ², Nicolò D’Addario ², Lorenzo Cerroni ², Alexandra Nistor ², Daniele Gianfrilli ², Carlotta Pozza ², Andrea M. Isidori ^2
1 Department of Wellbeing, Health and Environmental Sustainability - BeSSA, Sapienza University of Rome, Rieti, Italy; ² Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

#A-0137

A-0137 Effect of age on seminal parameters – Findings from a large sample of Greek men
Themistoklis Vasileios Loumakos ¹, Evangelini Evgeni ¹, Lampros-Orion Asimakopoulos ², Georgios Kanakis ³, Byron Asimakopoulos ^2
1 Cryogonia Cryopreservation Bank, Athens, Greece; ² Laboratory of Physiology, Department of Medicine, Democritus University of Thrace, Greece; ³ Department of Endocrinology and Assisted Reproduction Unit, Naval and VA Hospital of Athens, Athens, Greece

#A-0138

A-0138 Effect of Tamoxifen on Semen Parameters in Patients with Severe Oligoasthenozoospermia and Primary Testiculopathy with Hypospermatogenesis
Giuseppe Grande ¹, Andrea Graziani ^1,2, Luis Lopez-Fando ^3,4, Pierfrancesco Palego ¹, Alberto Scala ², Riccardo Selice ¹, Alberto Ferlin ^1,2
1 University Hospital of Padua, Department of Medicine, Unit of Andrology and Reproductive Medicine, Padua, Italy; ² University of Padua, Department of Medicine, Padua, Italy; ³ Hospital Universitario La Princesa, Department of Urology, Madrid, Spain; ⁴ UROLF Clinic, Madrid, Spain

#A-0140

A-0140 Residual Testicular Volume Determines Early Semen Parameter Changes After Orchiectomy in Testicular Cancer
Andrea Graziani ^1,2, Giuseppe Grande ¹, Alberto Scala ², Nicola Caretta ¹, Antonella Di Mambro ¹, Andrea Garolla ^1,2, Pierfrancesco Palego ¹, Riccardo Selice ¹, Alberto Ferlin ^1,2
1 University Hospital of Padua, Department of Medicine, Unit of Andrology and Reproductive Medicine, Padua, Italy; ² University of Padua, Department of Medicine, Padua, Italy

#A-0144

A-0144 Whole exome sequencing in the diagnosis of male infertility associated with severe astheno-/teratozoospermia
Olga Solovova ¹, Oxana Ryzhkova ¹, Elizaveta Bragina ^1,2, Maria Shtaut ¹, Sabina Khayat ¹, Vyacheslav Chernykh ^1,3
1 Research Centre for Medical Genetics, Moscow, Russia; ² Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia; ³ Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation, Moscow, Russia

#A-0145

A-0145 Unmasking Primary Hypogonadism After Significant Weight Loss Induced by Tirzepatide in a Male Survivor of Hodgkin and Non-Hodgkin Lymphoma
Nicolò Francesco D'Addario, Francesco Carlomagno, Lorenzo Cerroni, Elisabetta Vozza, Carlotta Pozza, Daniele Gianfrilli, Andrea Isidori
Dipartimento di Medicina Sperimentale, Azienda Ospedaliera Universitaria Policlinico Umberto I, Università degli Studi di Roma la Sapienza, Italy

#A-0146

A-0146 Post-vasectomy pain syndrome and vasectomy complications
Maurizio De Rocco Ponce ¹, Massimiliano Raffo ^2,3, Doron Vantman Luft ¹, Francesco Montorsi ^2,3, Andrea Salonia ^2,3, Eduard Ruiz-Castañe ^1
1 Fundaciò Puigvert, Andrology Department, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau) Barcelona, Spain; ² Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; ³ University Vita-Salute San Raffaele, Milan, Italy

#A-0147

A-0147 High-grade aneuploidies of sex chromosomes with male phenotype: an Endo-ERN survey
Matteo Spaziani ^1,2, Francesco Carlomagno ¹, Emilia Sbardella ¹, Chiara Tarantino ¹, Ludovica Vincenzi ¹, Arianna Gagliardi ¹, Valeria Ferretti ¹, Marco Ippoliti ¹, Carlotta Pozza ¹, Daniele Gianfrilli ¹, Andrea M. Isidori ^1
1 Section of Medical Pathophysiology and Endocrinology, Department of Experimental Medicine, Sapienza University, of Rome, Rome, Italy; ² Department of Theorethical and Applied Sciences, eCampus University, Novedrate, Italy

#A-0149

A-0149 Would a PDE5-inhibitor non-responders with erectyle dysfunction and compensated diabetes mellitus benefit from dapagliflozin association?
Victoria Ghenciu, Iurii Arian, Mariana Creciun, Ion Dumbraveanu
Lab of Urology, Andrology and Reproductive Medicine, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova

#A-0151

A-0151 Impact of levator ani muscle injuries on female sexual function in the postpartum period
Birafane Hasnaa, Aboutaieb Rachid
University Hassan II, Casablanca, Morocco

#A-0153

A-0153 TESA and m-TESE in men with azoospermia after oncological treatment
Jan Karol Wolski ¹, Grzegorz Kapuściński ¹, Mateusz Wideński ¹, Katarzyna Kozioł ¹, Dariusz Starczewski ¹, Bogdan Biarda ¹, Marcin Kołacz ¹, Karina Gawron ¹, Karolina Korczyńska ¹, Adriana Strzałkowska ¹, Bartosz Sierakowski ¹, Jacek Judycki ¹, Joanna Ostrowska ², Agnieszka Sobczyńska-Tomaszewska ³, Jan Lewandowski ¹, Piotr Lewandowski ^1
1 Fertility Clinic Novum, Warsaw, Poland; ² Center for Pathomorphological Diagnostics, Warsaw, Poland; ³ MEGDEN, Medical Center, Warsaw, Poland

#A-0157

A-0157 Effects of glucagon-like peptide 1 receptor agonists on testicular dysfunction: A systematic review and meta-analysis
G. Salvio, A. Ciarloni, N. Ambo, M. Bordoni, V. Di Giacomi, M. Perrone, S. Rossi, G. Balercia
Endocrinology Clinic, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy

#A-0158

A-0158 The effects of stress on the mammalian blood-testis barrier
Bongekile Skosana, Yashthi Ramsunder, Lisa Marie Ferguson, Lihle Qulu-Appiah
Division of Medical Physiology, Faculty of Medicine and health Sciences, Stellenbosch University

#A-0159

A-0159 Distal Penile Gangrene following Winter's shunt For Ischeamic Priapism

#A-0160

A-0160 Research Protocol: Validation of the Animal Model for the Study of the Pudendal Nerve: A Comparative Cadaveric, Morphometric, and Histological Study in Rabbits, Goats, Sheep, and Humans
A El Baz ¹, K El Allali ², R Aboutaieb ^1
1 Laboratory of Sexual and Reproductive Health, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco; ² Hassan II Agronomic and Veterinary Institute, Rabat, Morocco

#A-0207

A-0207 Androgen sensitivity and hypogonadotropic hypogonadism correlate differently and independently with cardiovascular risk in severe obesity
Alessandro Chilà* ¹, Gabriele Pogliaghi ^1,2, Ilaria Gentile ^1,2, Nicoletta Del Duca ³, Alice Casiraghi ¹, Ilinka Garavaglia ¹, Alessandro Amodeo ¹, Martina Sculco ⁴, Valeria Vezzoli ², Roberta Cirillo ³, Alessandra Milesi ³, Stefania Mai ³, Luca Persani ^1,2, Massimo Scacchi ^3,5, Marco Bonomi ^1,2, Biagio Cangiano* ^1,2
1 Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy; ² Istituto Auxologico Italiano IRCCS, Division of Endocrine and Metabolic Diseases, Milan, Italy; ³ Istituto Auxologico Italiano IRCCS, Division of General Medicine, San Giuseppe Hospital, Oggebbio-Piancavallo, Verbania, Italy; ⁴ University of Milan, Milan, Italy; ⁵ Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

#A-0208

A-0208 Impact of Chemotherapy on Sperm Functional Characteristics in Patients With Testicular Germ Cell Tumours
Ondrej Sanovec ^1,2, Ondrej Simonik ¹, Zuzana Kratka ³, Lukas Ded ¹, Jana Vondrakova ¹, Maryam Qasemi ¹, Barbora Bryndova ^1,4, Michala Krejci ¹, Daniela Spevakova ¹, Vishma Pratap Sur ¹, Radomir Kren ⁵, Tomas Hradec ⁶, Pavel Skrobanek ⁷, Ludmila Boublikova ⁷, Libor Zamecnik ⁶, Tomas Buchler ^7,8, Jiri Neuzil ^9,10, Pavla Postlerova ¹, Katerina Komrskova ^1,11
1 Laboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic; ² Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic; ³ Laboratory of Immunology, IVF Clinic GENNET, Prague, Czech Republic; ⁴ Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic; ⁵ Laboratory of Embryology, IVF Clinic GENNET, Prague, Czech Republic; ⁶ Department of Urology, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic; ⁷ Department of Oncology, First Faculty of Medicine, Charles University and Thomayer University Hospital, Prague, Czech Republic; ⁸ Department of Oncology, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic; ⁹ Laboratory of Molecular Therapy, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic; ¹⁰ School of Pharmacy and Medical Science, Griffith University, Southport, Australia; ¹¹ Department of Zoology, Faculty of Science, Charles University, Prague, Czech Republic

#A-0209

A-0209 The effects of varicocele on semen parameters and reproductive hormones
Lionel Wildy Moungala ^1,2
1 Reproductive Scientist, Androcryos/Ampath Andrology Laboratory, Johannesburg, South Africa; ² Extraordinary lecturer, Department of Urology, University of Pretoria, South Africa

#A-0212

A-0212 Steatosis Indices and Penile Vascular Health: Rethinking the Liver–Erection Axis
Massimiliano Ugoccioni ^1,2, Elisa Gatta ¹, Sara Manelli ¹, Caterina Zoccoletto ¹, Loubna Enezari ¹, Andrea Graziani ³, Ilenia Pirola ¹, Andrea Delbarba ^1
1 Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; ² Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; ³ Department of Medicine, University of Padova, Padova, Italy

#A-0214

A-0214 Efficacy and safety of transurethral seminal vesiculoscopy for oligo-astheno-teratozoospermia: A systematic review and meta-analysis
Chui Ka Lun
The Chinese University of Hong Kong

#A-0216

A-0216 Driving diagnostic excellence: 25 Years of External Quality Assessment (EQA) in Y Chromosome microdeletion testing
P. Navarro-Costa ¹, J. Steingröver ², D. Westra ³, M. Wilke ⁴, L. Hoefsloot ^3,4, M. Simoni ⁵, S. Patton ⁶, F. Tüttelmann ², C. Krausz ^7
1 Lisbon School of Medicine, Portugal; ² Institute of Reproductive Genetics, Centre of Medical Genetics. University of Münster, Germany; ³ Radboud University Medical Centre Nijmegen, The Netherlands; ⁴ Erasmus Medical Center, Rotterdam, The Netherlands; ⁵ University of Modena and Reggio Emilia, Italy; ⁶ EMQN CIC, United Kingdom; ⁷ University of Florence, Italy

#A-0218

A-0218 Testosterone protects from metabolic syndrome-associated lung dysfunction in a high-fat diet rabbit model
Giulia Guarnieri ¹, Giulia Rastrelli ², Paolo Comeglio ², Sandra Filippi ³, Ilaria Cellai ², Gabriele Acciai ², Gianluca Bartolucci ³, Alessandro Pini ¹, Amedeo Amedei ¹, Ludovico Silvestri ⁴, Rachele Garella ¹, Maria Emanuela Ragosta ², Sarah Cipriani ², Sara Marchiani ², Mario Maggi ², Annamaria Morelli ¹, Linda Vignozzi ^2
1 Department of Experimental and Clinical Medicine, University of Florence, Italy; ² Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Italy; ³ Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Italy; ⁴ European Laboratory for Non-Linear Spectroscopy (LENS) Sesto Fiorentino, University of Florence, Italy

#A-0219

A-0219 Enzyme-mediated generation of DNA double-strand breaks reveal accessible sperm chromatin regions
Adrián Barba-García, Noelia Lopez-Villón, Irina Guerrero-Fontiveros, Ariadna Delgado-Bermúdez, Jordi Ribas-Maynou
Unit of Cell Biology and Medical Genetics, Department of Cell Biology, Physiology and Immunology, Autonomous University of Barcelona, Bellaterra, Spain

#A-0220

A-0220 Clinical and genetic features of a large cohort of patients with Klinefelter syndrome (KS) referred to a tertiary referral center
S Colombo ¹, A Chilà ¹, L Colombini ¹, B Cangiano ^1,2, S Federici ², L Giovanelli ¹, M Moro ², L Persani ^1,2, M Bonomi ^1,2, G Goggi ^2
1 Department of Medical Biotechnology and Translational Medicine – University of Milan, Milan, Italy; ² Endocrine and Metabolic Department, Gynecological and Andrological Endocrinology Unit – IRCCS Istituto Auxologico Italiano, Milan, Italy

#A-0221

A-0221 Changes in IIEF, PEDT and Orgasmometer Scores According to Attachment Styles as Measured by the Relationship Questionnaire
Andrea Sansone ¹, Daniele Mollaioli ², Sara di Paola ¹, Elena Colonnello ¹, Giacomo Ciocca ³, Emmanuele A. Jannini ^4
1 Section of Endocrinology and Medical Sexology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; ² Department of Dynamic and Clinical Psychology, and Health Studies, Sapienza University of Rome, Rome, Italy; ³ Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy; ⁴ Chair of Endocrinology and Medical Sexology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

#A-0223

A-0223 Age disparity in couples and the sexual and general health of the male partner
Clotilde Sparano ¹, Giulia Rastrelli ², Giovanni Corona ³, Linda Vignozzi ², Daniele Vignoli ⁴, Mario Maggi ^1
1 Endocrinology Unit, 'Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; ² Andrology, Women's Endocrinology and Gender Incongruence Unit, 'Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; ³ Endocrinology Unit, Azienda AUSL, Maggiore Hospital, Bologna, Italy; ⁴ Department of Statistics, Computer Science, Applications, University of Florence, Florence, Italy

#A-0224

A-0224 Anthropometric and psychosocial parameters in young adults with craniopharyngioma-related hypothalamic obesity treated with low-dose setmelanotide: a pilot observational study
Ilaria Cotugno ¹, Alessio Bombardieri ¹, Michela Cirillo ¹, Giovanni Corona ³, Linda Vignozzi ¹, Mario Maggi ², Giulia Rastrelli ^1
1 Andrology and Gender Endocrinology Unit, Careggi Hospital, Florence, Italy; ² Endocrinology Unit, Mario Serio Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy; ³ Endocrinology and Metabolic Diseases, AUSL Romagna, Forli'-Cesena, Italy

#A-0227

A-0227 Phenotyping of male factor infertility and development of a new pathophysiology-based diagnostic classification: evidence from a 700-patient clinical cohort
Giuseppe Grande ¹, Andrea Graziani ^1,2, Nicola Caretta ¹, Antonella Di Mambro ¹, Andrea Garolla ^1,2, Giulia Masi ^1,2, Pierfrancesco Palego ¹, Maia Santa Rocca ¹, Alberto Scala ^1,2, Riccardo Selice ¹, Cinzia Vinanzi ¹, Luca De Toni ², Alberto Ferlin ^1,2
1 Unit of Andrology and Reproductive Medicine, Department of Systems Medicine, University Hospital of Padova, Padova, Italy; ² Department of Medicine, University of Padova, Padova, Italy

#A-0228

A-0228 Results of the national Reproductive health screening program of the population of the Russian Federation: two years and nearly 10 million participants experience
Oleg Apolikhin ¹, Stepan Krasnyak ^2
1 N.A. Lopatkin Research Institute of Urology and Interventional Radiology - branch of the Federal State Budgetary Institution «NMRRC» of the Ministry of Health of the Russian Federation, Moscow, Russia

#A-0234

A-0234 Hanging in the balance: Understanding the importance of sperm ROS for pre-implantation embryo development
Joshua Deluao ^1,2, Hannah Lyons ^1,2, Macarena Gonzalez ^1,2, Mark Nottle ^1,2, Nicole McPherson ^1,2,3
1 Adelaide University, Adelaide, AUS; ² Robinson Research Institute, Adelaide, AUS; ³ Genea, Sydney, AUS

#A-0238

A-0238 Sexual Health Interventions in People Living with HIV (PLWH): A Systematic Review
Ramona Di Stefano ¹, Lorenzo Vittorio Rindi ², Andrea Sansone ¹, Tommaso B Jannini ³, Mirko Compagno ^2,4, Elisabetta Teti ⁴, Daniele Gianfrilli ⁵, Loredana Sarmati ⁴, Emmanuele A. Jannini ^6
1 Section of Endocrinology and Medical Sexology (ENDOSEX) Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; ² PhD Course in Microbiology, Immunology, Infectious Diseases, and Transplants (MIMIT) University of Rome 'Tor Vergata', Rome, Italy; ³ Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy; ⁴ Infectious Diseases, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; ⁵ Section of Medical Pathophysiology and Endocrinology, Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy; ⁶ Chair of Endocrinology and Medical Sexology (ENDOSEX) Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

#A-0239

A-0239 Insulin-like peptide 3 (INSL3) for monitoring progress and recovery of hypogonadism in men
Ravinder Anand-Ivell, Xinyuan Yang, Bilal Tulumcu, Richard Ivell
University of Nottingham, UK

#A-0243

A-0243 Revisiting male infertility: insights into sexual dysfunction from a meta-analysis
Giorgia Spaggiari ^1,2,3, Giovanni Corona ⁴, Valentina Griseta ^1,2, Manuela Simoni ^1,2, Daniele Santi ^1,2,3
1 Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; ² Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy; ³ Unit of Andrology and Sexual Medicine of the Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy; ⁴ Endocrinology and Metabolic Diseases, AUSL Romagna, Forlì-Cesena, Italy

#A-0244

A-0244 Infertility-Related Stress and Hypothalamic–Pituitary–Adrenal Axis Function in Patients Undergoing Assisted Reproductive Technologies: From Psychometric Assessment to Endocrine Biomarkers
Giulia Pocaterra ^1,2, Valentina Griseta ^1,2, Daniele Renda Livraghi ^1,2, Antoan Stefan Sojat ⁴, Ljiljana V Marina ⁵, Mina Hagen ⁶, Antonio Raffaele Michele Granata ^2,3, Manuela Simoni ^1,2, Francesco Costantino ^1,2, Giorgia Spaggiari ^1,2,3, Daniele Santi ^1,2,3
1 Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; ² Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy; ³ Unit of Andrology and Sexual Medicine, Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy; ⁴ National Centre for Infertility and Endocrinology of Gender, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Serbia, Belgrade, Serbia; ⁵ Department for Obesity, Reproductive and Metabolic Disorders, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Serbia, Belgrade, Serbia; ⁶ Department of Psychology, Faculty for media and Communications, Singidunum University, Belgrade, Serbia

#A-0245

A-0245 Fresh versus cryopreserved Microtese sperm in NOA: ICSI outcomes and the impact of severe testicular histology
Giovanni Maria Colpi ¹, Elisabetta Piatti ¹, Gianmarco Momi ¹, Marina Bellavia ¹, Marjan Sabbaghian ², Giacomo Gazzano ³, Germar-Michael Pinggera ⁴, Ettore Caroppo ^5
1 Andrology and IVF Center, Next Fertility Procrea, Lugano, Switzerland; ² Dept. of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran; ³ Pathology Unit, Istituto Auxologico Italiano IRCCS, Milano, Italy; ⁴ Dept. of Urology, Medical University Innsbruck, Innsbruck, Austria; ⁵ Andrology Outpatients Clinic, ASL Bari, PTA "F Jaia," Conversano, Bari, Italy

#A-0247

A-0247 Methotrexate toxicity on human spermatozoa: An in vitro study of the effect on sperm motility through, oxidative stress and DNA integrity
Amira Sallem ^1,2, Amira Dhaoui ^1,2, Manel Boussabbeh ¹, Faouez Boujelben ¹, Narjes Trabelsi ¹, Ranin Selmi ^1,2, Elhem Ghodhbane ¹, Meriem Mehdi ^1
1 Department of Reproductive Biology, Maternity and Neonatology Center of Monastir, Fattouma Bourguiba University Teaching Hospital, Monastir, Tunisia; ² Research Laboratory 'Environment, Inflammation, Signaling and Pathologies' (LR18ES40) Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia

#A-0250

A-0250 Evidence for a cross-protection activity towards non-vaccine genotypes, in male subjects receiving HPV-nonavalent vaccine for co-infection/recurrence control purposes
Luca De Toni, Silvia Mereu, Andrea Graziani, Giuseppe Grande, Alberto Ferlin, Andrea Garolla
Unit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, Padova, Italy

#A-0251

A-0251 Effect of temperature variations on semen parameters in an infertile population_A focus on morphological abnormalities
Maissa Benamara ¹, Amira Sallem ^1,2, Manel Boussabbeh ¹, Amira Dhaoui ¹, Nesrine Haj Mtir ¹, Ranin Selmi ¹, Meriem Mehdi ^1
1 Department of Reproductive Biology, Maternity and Neonatology Center, Fattouma Bourguiba University Teaching Hospital, Monastir Tunisia; ² Laboratory of Histology-Embryology and Cytogenetics, (LR 18 ES 40) Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia

#A-0252

A-0252 Hypogonadism as a part of a rare disease spectrum
Marija Miletić, Milina Tančić-Gajić, Veljko Pantović, Taisa Bojović, Svetlana Vujović
University Clinical Center of Serbia, Clinic for endocrinology, diabetes and diseases of methabolism

#A-0253

A-0253 Patchs in Peyronie’s disease implant surgery: failure of the collagen fleece fibrin sealant patch, revised by a bovine pericardium patch. Clinical case
Edoardo Pescatori, Andrea Loreto
Andrology Unit, Casa di Cura Città di Parma, Parma - ITALY

#A-0254

A-0254 Impact of Varicocele Repair using high retro-peritoneal technique and sub-inguinal approach on Semen Parameters in a resource-limited setting
Aziz Bhouri ¹, Amira Sallem ^2,3, Med Helmi Tabka ¹, Manel Boussabbeh ², Mounir Touffahi ¹, Meriem Mehdi ^2
1 Department of Urology, Fattouma Bourguiba University Teaching Hospital, Monastir, Tunisia; ² Department of Reproductive Biology, Maternity and Neonatology Center of Monastir, Fattouma Bourguiba University Hospital, Monastir, Tunisia; ³ Research Laboratory 'Environment, Inflammation, Signaling and Pathologies' (LR18ES40) Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia

#A-0257

A-0257 Penile prosthesis infection and diabetes mellitus: a systematic review and meta-analysis
Wai Gin (Don), Lee ^1,2, Paolo Capogrosso ³, Javier Romero Otero ⁴, Andrea Salonia ^5,6, Yacow Reisman ⁷, Carlo Bettocchi ⁸, Mario Maggi ⁹, Mikkel Fode ^10,11, Giovanni Corona ^12
1 Department of Urology, University College London Hospitals, London, UK; ² St Peter's Andrology, London, UK; ³ Department of Urology and Andrology, Ospedale di Circolo and Macchi Foundation, Varese, Italy; ⁴ Department of Urology, Hospital Universitario HM Sanchinarro, HM Hospitales and ROC Clinic, Madrid, Spain; ⁵ Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; ⁶ Vita-Salute San Raffaele University, Milan, Italy; ⁷ Amstelland Hospital, Amstelveen, the Netherlands; ⁸ Andrology and Male Genitalia Reconstructive Surgery Unit, University of Foggia, Foggia, Italy; ⁹ Endocrinology Unit, Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; ¹⁰ Department of Urology, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark; ¹¹ Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; ¹² Endocrinology and Metabolic Disease Unit, AUSL Romagna, Forlì-Cesena Italy

#A-0258

A-0258 Long-term penile prosthesis couple’s satisfaction: a systematic review and meta-analysis
Oorja Verma ^1,2, Walter Vena ^1,2, Daniele Santi ³, Andrea Cocci ⁴, Alessandro Pizzocaro ⁵, Linda Vignozzi ⁶, Andrea M Isidori ⁷, Rosario Pivonello ^8,9, Andrea Salonia ^10,11, Carlo Bettocchi ¹², Yacov Reisman ¹³, Giulia Rastrelli ⁶, Mario Maggi ¹⁴, Giovanni Corona ^15
1 Endocrinology, Humanitas Gavazzeni-Castelli, Bergamo, Italy; ² Department of Biomedical Sciences, Humanitas University, Milan, Italy; ³ Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy; ⁴ Department of Urology, University of Florence, Florence, Italy; ⁵ Unit of Endocrinology, Diabetology and Medical Andrology, IRCSS, Humanitas Research Hospital, Rozzano, Milan, Italy; ⁶ Andrology, Women's Endocrinology and Gender Incongruence Unit, Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; ⁷ Department of Experimental Medicine, ʺSapienzaʺ University of Rome, Policlinico Umberto I Hospital, Rome, Italy; ⁸ Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Unità di Andrologia e Medicina della Riproduzione e della Sessualità Maschile e Femminile, Università Federico II di Napoli, Naples, Italy; ⁹ Staff of UNESCO, Chair for Health Education and Sustainable Development, Federico II University, Naples, Italy; ¹⁰ Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; ¹¹ University Vita-Salute San Raffaele, Milan, Italy; ¹² Andrology and Male Genitalia Reconstructive Surgery Unit, University of Foggia, Foggia, Italy; ¹³ Amstelland Hospital, Amstelveen, the Netherlands; ¹⁴ Endocrinology Unit, Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; ¹⁵ Endocrinology and Metabolic Disease Unit, AUSL Romagna, Forli’-Cesena, Italy

#A-0259

A-0259 Testosterone therapy after radical prostatectomy: insights from a systematic review and meta-analysis
Paolo Capogrosso ¹, Luís Afonso Morgado ², Luca Boeri ³, Carlo Bettocchi ⁴, Giulia Rastrelli ⁵, Linda Vignozzi ⁵, Mario Maggi ⁶, Andrea Salonia ^7,8, Giovanni Corona ^9
1 Department of Urology and Andrology, Ospedale di Circolo and Macchi Foundation, Varese, Italy; ² Urology Service, Centro Hospitalar Universitário São João, Porto, Portugal, Department of Biomedicine, Faculty of Medicine, Porto University, Porto, Portugal; ³ Department of Urology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; ⁴ Department of Urology, University of Foggia, Foggia, Italy; ⁵ Andrology, Women's Endocrinology and Gender Incongruence Unit, Department of Experimental, Clinical, and Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy; ⁶ Endocrinology Unit, Department of Experimental, Clinical, and Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy; ⁷ Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; ⁸ Vita-Salute San Raffaele University, Milan, Italy: ⁹ Endocrinology and Metabolic Disease Unit, Specialist Medicine Department, AUSL Romagna, Forlì-Cesena, Italy

#A-0260

A-0260 Unravelling deregulated metabolites in the seminal plasma of infertile men: a systematic review and bioinformatic analysis
Rafael Santos ¹, Beatriz Marinheiro ¹, Margarida Ramos ¹, Pedro F. Oliveira ², Pedro O. Corda ¹, Margarida Fardilha ¹, Joana Santiago ^1
1 Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; ² LAQV/REQUIMTE, Department of Chemistry, University of Aveiro, Portugal\r\n

#A-0265

A-0265 Complete AZF and gr/gr deletions in infertile men: 21-year diagnostic experience and clinical implications
Chiara Abrardo ¹, Elisabet Ars ², Viola Bonini ³, Matilde Spinelli ¹, Daniel Moreno-Mendoza ¹, Osvaldo Rajmil ¹, Josvany R Sánchez Curbelo ¹, Maurizio De Rocco Ponce ¹, Dorón Vantman Luft ¹, Alvaro Vives ¹, Antoni Riera-Escamilla ¹, Eduard Ruiz-Castané ¹, Csilla Krausz ^3
1 Department of Andrology, Fundació Puigvert, Instituto De Investigaciones Biomédicas Sant Pau (IIB-Sant Pau) Barcelona, Catalonia, Spain; ² Molecular Biology Laboratory, Fundació Puigvert, Institut de Recerca Sant Pau (IR-Sant Pau) Universitat Autònoma de Barcelona, Barcelona, Spain. RICORS2040; ³ Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy

#A-0267

A-0267 Fractionated Testosterone Gel Replacement Therapy in Clinical Practice: A Real-World Clinical Experience
Virginia Maltese ¹, Andrea Delbarba ¹, Elisa Gatta ¹, Simone Vetrugno ², Andrea Sansone ³, Carlo Cappelli ^1
1 Department of Clinical and Experimental Sciences, Endocrine and Metabolic Unit, University of Brescia, Azienda Socio-Sanitaria Territoriale (ASST) Spedali Civili di Brescia, Brescia, Italy; ² Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; ³ Section of Endocrinology and Sexual Medicine (ENDOSEX) Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy

#A-0268

A-0268 The effect of psychotropic medications on sperm parameters
Britt R. Balvers ^1,2, Emma Schram ^1,2, Isabel Quak ¹, Ans M. van Pelt ^1,2, Norah van Mello ^2,3,4, Callista L. Mulder ^1,2
1 Reproductive Biology Laboratory, Center for Reproductive Medicine, Amsterdam University Medical Center, location Academic Medical Center, Amsterdam, The Netherlands; ² Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands; ³ Centre of Expertise on Gender Dysphoria, Amsterdam University Medical Center, Location Vrije Universiteit Medical Center, Amsterdam, The Netherlands; ⁴ Department of Obstetrics & Gynaecology, Amsterdam University Medical Center, location Vrije Universiteit Medical Center, Amsterdam, The Netherlands

#A-0270

A-0270 Smoking-Associated Decline in Semen Quality Linked to Activation of Sperm Stress Pathways
Magda Carvalho Henriques ^1,3, Joana Santiago ¹, Maria Teresa Herdeiro ¹, António Patrício ², Susana Loureiro ³, Margarida Fardilha ^1
1 Department of Medical Sciences, Institute of Biomedicine (iBiMED) University of Aveiro, Aveiro, Portugal; ² Centro Hospitalar do Baixo Vouga, Hospital Infante D. Pedro, Aveiro, Portugal; ³ Department of Biology, Centro de Estudos do Ambiente e do MAR (CESAM) University of Aveiro, Aveiro, Portugal

#A-0272

A-0272 “It’s not you, it’s the butterfly effect”: development of a conceptual framework for the Chaos Theory in sexual medicine
Andrea Sansone ¹, Sara Di Paola ¹, Syria Sinopoli ¹, Elena Colonnello ¹, Emmanuele A. Jannini ^2
1 Section of Endocrinology and Medical Sexology (ENDOSEX) Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; ² Chair of Endocrinology and Medical Sexology (ENDOSEX) Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

#A-0273

A-0273 Does low intensity shockwave treatment (LISWT) affect cavernosal vascular factors in erectile dysfunction? A pilot study
Giovanni Badioli ¹, Myriam Amer ¹, Vincenzo Maria Altieri ², Eleonora Vitali ³, Liborio Vaccalluzzo ¹, Maria Cristina D'Agostino ⁴, Emanuela Morenghi ⁵, Giovanni Corona ⁶, Sara Maria Giulia Cioffi ⁷, Antonio Carlo Bossi ^8,9, Andrea Gerardo Lania ^1,8, Walter Vena ^8,9, Alessandro Pizzocaro ^1
1 Endocrinology, Diabetology and Andrology Unit, Humanitas Clinical and Research Center, IRCCS, Rozzano, MI, Italy; ² Department of Medicine and Health Sciences “V.Tiberio”, University of Molise, Campobasso, Italy; ³ Laboratory of Translational Endocrinology and Metabolism, IRCCS Humanitas Research Hospital, Rozzano, Italy; ⁴ Extracorporeal Shock Wave Unit, Rehabilitation Department, Humanitas Clinical and Research Center, IRCCS Rozzano, Milan, Italy; ⁵ Biostatistics Unit, Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy; ⁶ Endocrinology and Metabolic Disease Unit, AUSL Romagna, Forlì-Cesena, Italy; ⁷ Laboratory Medicine, Humanitas Clinical and Research Center - IRCCS, Rozzano, Italy; ⁸ Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy; ⁹ Endocrinology and Diabetology Unit, Humanitas Gavazzeni Institute, Bergamo, Italy

#A-0274

A-0274 Anti-hypertensive medications and erectile dysfunction: focus on β-blockers
Giovanni Badioli ¹, Walter Vena ^2,3, Gianmaria Salvio ⁴, Clotilde Sparano ⁵, Alessandra Sforza ⁶, Mario Maggi ⁵, Alessandro Pizzocaro ¹, Giovanni Corona ^6
1 Endocrinology, Diabetology and Andrology Unit, Humanitas Clinical and Research Center, IRCCS, Rozzano, MI, Italy; ² Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy; ³ Endocrinology and Diabetology Unit, Humanitas Gavazzeni Institute, Bergamo, Italy; ⁴ Endocrinology Clinic, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy; ⁵ Endocrinology Unit Department of Experimental, Clinical and Biomedical Sciences, University of Florence, Florence, Italy; ⁶ Endocrinology Unit, Maggiore Hospital, Azienda-Usl Bologna, Bologna, Italy

#A-0276

A-0276 Cardiovascular safety of testosterone replacement therapy in men: an updated systematic review and meta-analysis
Giovanni Corona ¹, Giulia Rastrelli ², Clotilde Sparano ³, Valeria Carinci ⁴, Gianni Casella ⁴, Linda Vignozzi ², Alessandra Sforza ⁵, Mario Maggi ^3
1 Endocrinology and Metabolic Diseases, AUSL Romagna, Forli'-Cesena, Italy.; ² Andrology, Women's Endocrinology and Gender Incongruence Unit, Mario Serio" Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; ³ Endocrinology Unit, Mario Serio" Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; ⁴ Cardiology Unit, Azienda AUSL, Maggiore Hospital, Bologna, Italy; ⁵ Endocrinology Unit, Azienda AUSL, Maggiore Hospital, Bologna, Italy

#A-0280

A-0280 Crocin: A Promising Antioxidant for Sperm Motility Improvement
Manel Boussabbeh ^1,2, Amira Sallem ^1,3, Manel Haddar ², Abir Chaieb ², Rania Khdhiri ², Meriem Mehdi ¹, Salwa Abid-Essefi ^2
1 Reproductive Biology Service, Maternity and Neonatology Center of Monastir, Fattouma Borguiba University Hospital, Monastir, Tunisia; ² Laboratory of Research on Biologically Compatible Substances, University of Monastir, Monastir, Tunisia; ³ Environment, Inflammation, Signaling and Pathologies; (LR18ES40) Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia

#A-0281

A-0281 Effects of Cadmium from Active and Passive Smoking on Sperm Quality in Male Partners of Infertile Couples: Impact on Sperm Parameters, DNA Fragmentation, and Decondensation
Jihane Ait Benbella ¹, Mouad Elbader ², Samy Housbane ³, Noureddine Louanjli ⁴, Achraf Zakaria ⁴, Othmane Ham-mani ⁵, Rachid Aboutaieb ^1,2
1 Laboratory of Sexual and Reproductive Health. Faculty of Medicine and Pharmacy, Hassan II University Casablanca, Morocco; ² Department of Urology, CHU Ibn Rochd, Casablanca, Morocco; ³ Department of Medical Informatics, Faculty of Medicine and Pharmacy, Hassan II University Casablanca, Morocco; ⁴ Labomac IVF Center and Clinical Laboratory Medicine, Casablanca, Morocco; ⁵ National Center for Scientific and Technical Research (CNRST), Rabat, Morocco

#A-0282

A-0282 Crocin promotes mitochondrial efficiency in asthenozoospermic samples
Manel Boussabbeh ^1,2, Amira Sallem ^1,3, Abir Chaieb ², Manel Haddar ², Rania Khdhiri ², Salwa Abid-Essefi ², Meriem Mehdi ^1
1 Reproductive Biology Service, Maternity and Neonatology Center of Monastir, Fattouma Borguiba University Hospital, Monastir, Tunisia; ² Laboratory of Research on Biologically Compatible Substances, University of Monastir, Monastir, Tunisia; ³ Environment, Inflammation, Signaling and Pathologies (LR18ES40), Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia

#A-0283

A-0283 Testosterone in Iron Overload: Essential for Bone, Not Sufficient Alone
Francesca Paglia¹, Sara Cerrato¹, Fabrizia Bracalello¹, Barbara Rossi¹, Anna Ansaloni², Selene Evangelisti¹, Sara De Vincentis¹, Vincenzo Rochira^1,2
1 Endocrinology, Department of Biomedical, Metabolic and Neuroscience Sciences, University of Modena and Reggio Emilia, Modena, Italy; ² Unit of Endocrinology, Department of Specialized Medicine, Modena University Hospital, Modena, Italy

#A-0284

A-0284 Sperm DNA fragmentation: Comparative insights from four assays
Manel Boussabbeh ^1,2, Amira Sallem ^1,3, Yasmine Boughammoura ² Ghodhbane Elhem ³, Dhaoui Amira ³, Faouez Boujelben ⁴, Salwa Abid-Essefi ², Meriem Mehdi ^1
1 Reproductive Biology Service, Maternity and Neonatology Center of Monastir, Fattouma Borguiba University Hospital, Monastir, Tunisia; ² Laboratory of Research on Biologically Compatible Substances, University of Monastir, Monastir, Tunisia; ³ Environment, Inflammation, Signaling and Pathologies (LR18ES40), Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia ; ⁴ Research Laboratory 'Histophysiology of Developmental Pathologies and Induced Pathologies', Medical School of Sfax, Sfax, Tunisia

#A-0288

A-0288 Septin 12 localizes to the manchette and perinuclear ring during spermiogenesis
Michaela Frolikova ¹, Ondrej Sanovec ¹, Ivan Novotny ², Katerina Komrskova ^1,3
1 Laboratory of Reproductive Biology, Institute of Biotechnology CAS, v.v.i., BIOCEV, Vestec, Czech Republic; ² Light Microscopy Core Facility, Institute of Molecular Genetics CAS v.v.i., Prague, Czech Republic; ³ Department of Zoology, Faculty of Science, Charles University, Prague, Czech Republic

#A-0289

A-0289 Local host immune response against different types of bacteria in fertile and infertile men
Monika Fraczek ¹, Marzena Kamieniczna ¹, Lukasz Wojnar ², Laura Grzeskowiak ³, Karolina Luczkowska ⁴, Boguslaw Machalinski ⁴, Kamil Gill ⁵, Malgorzata Piasecka ⁵, Tomasz Wozniak ¹, Maciej Kurpisz ^1
1 Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland; ² Private Andrological Practice, Poznan, Poland; ³ Certus Private Hospital, Poznan, Poland; ⁴ Department of General Pathology, Faculty of Medicine and Dentistry, Pomeranian Medical University in Szczecin, Szczecin, Poland; ⁵ Department of Histology and Developmental Biology, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, Szczecin, Poland

#A-0290

A-0290 The use of regenerative technologies in peyronie\'s disease management: corporoplasty using a pericardial allograft
Valentin Pavlov, Rustem Kazikhinurov, Andranik Vardikian
Clinic of Bashkir State Medical University, Ufa, Russia

#A-0293

A-0293 Characteristics of Secondary Hypogonadism defined by LH levels but with elevated FSH: findings from a cohort of men seeking specialist evaluation for Sexual Dysfunction
Bombardieri Alessio ¹, Cotugno Ilaria ¹, Corona Giovanni ², Vignozzi Linda ¹, Maggi Mario ³, Rastrelli Giulia ^1
1 Andrology and Gender Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences \\\"Mario Serio\\\", University of Florence, Florence, Italy; ² Endocrinology and Metabolic Disease Unit, AUSL Romagna, Ospedale Morgagni-Pierantoni, 47121, Forlì (FC), Italy; ³ Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences \\\"Mario Serio\\\", University of Florence, Florence, Italy

#A-0294

A-0294 Sperm motility impairment: A study of oxidative and mitochondrial parameters
Manel Boussabbeh ¹, Amira Sallem ^1,3, Abir Chaieb ², Roubé Bettaieb ², Rania Kdhiri ², Salwa Abid Essefi ², Meriem Mehdi ^1
1 Reproductive Biology Service, Maternity and Neonatology Center of Monastir, Fattouma Borguiba University Hospital, Monastir, Tunisia; ² Laboratory of Research on Biologically Compatible Substances, University of Monastir, Monastir, Tunisia; ³ Environment, Inflammation, Signaling and Pathologies (LR18ES40), Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia

#A-0295

A-0295 Evaluation of chronic widespread pain and its impact on sexual function and satisfaction
Bombardieri Alessio ¹, Cotugno Ilaria ¹, Corona Giovanni ², O'Neill Terence W. ³, Bártfai György ⁴, Casanueva Felipe F. ⁵, Forti Gianni ⁶, Giwercman Aleksander ⁷, Han Thang S. ⁸, Slowikowska-Hilczer Jolanta ⁹, Punab Margus ¹⁰, Antonio Leen ¹¹, Vanderschueren Dirk ¹¹, Huhtaniemi Ilpo T., Wu Frederick C. W., Maggi Mario ⁶, Rastrelli Giulia ^1
1 Andrology and Gender Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy; ² Endocrinology and Metabolic Disease Unit, AUSL Romagna, Ospedale Morgagni-Pierantoni, 47121, Forlì (FC), Italy; ³ Centre for Epidemiology Versus Arthritis, Manchester Biomedical Research Centre, The University of Manchester & NIHR, Manchester University NHS Foundation Trust, Manchester, UK; ⁴ Department of Obstetrics, Gynaecology and Andrology, Albert Szent-Gyorgy Medical University, Szeged, Hungary; ⁵ Department of Medicine, CIBER de Fisiopatología Obesidad y Nutricion, Instituto Salud Carlos III, , Santiago de Compostela University, Complejo Hospitalario Universitario de Santiago (IDIS), Santiago de Compostela, CB06/03, Spain; ⁶ Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy; ⁷ Reproductive Medicine Centre, Skåne University Hospital, University of Lund, Lund, Sweden; ⁸ Institute of Cardiovascular Research, Royal Holloway University of London, Egham, Surrey, UK; ⁹ Department of Andrology and Reproductive Endocrinology, Medical University of Łódź, Łódź, Poland; ¹⁰ Andrology Unit, Tartu University Hospital, Tartu, Estonia; ¹¹ Department of Andrology and Endocrinology, KU Leuven, Leuven, Belgium; Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium; ¹² Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Campus, London UK; ¹³ Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Medical and Human Sciences, Institute of Human Development, University of Manchester, Manchester, UK

#A-0296

A-0296 Intra-Individual Variation in Semen Quality: Analysis of 4,625 samples from 925 Semen Donors
Raphael Burkan Al-Najaar ^1,2, Ann Holm Hansen ^1,2, Laura Smidt Hansen ^1,2, Lærke Priskorn ^1,2, Dorte Egeberg ³, Niels Jørgensen ^1,2
1 Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, section 5064, Juliane Maries Vej 6, 2100 Copenhagen, Denmark; ² International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen 2100, Denmark; ³ European Sperm Bank, Copenhagen 2200, Denmark

#A-0299

A-0299 When Algorithms Meet Andrology: Can AI Chatbots Solve Clinical Cases?
Nesrine Haj Mtir ¹, Maissa Benamara ¹, Manel Boussabbeh ¹, Amira Dhaoui ¹, Meriem Mehdi ¹, Amira Sallem ^1,2
1 Department of Reproductive Biology, Maternity and Neonatology Center, Fattouma Bourguiba University Teaching Hospital, Monastir Tunisia; ² Laboratory of Histology-Embryology and Cytogenetics; (LR 18 ES 40) Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia

#A-0301

A-0301 Diagnostic Utility of Acetic Acid–Induced Acetowhite Change in Suspected Penile Intraepithelial Neoplasia
Jawwad Mihran Haider ¹, Syed Kamran ², Calum Clark ¹, Zhi-Yang Low ^1
1 Urology, St George's Hospital, London, UK; ² City St George's, University of London, UK

#A-0302

A-0302 Between a Rock and a Soft Spot: Finding the Right Layer for Hyaluronic Acid Intratunical Injection for Peyronie’s Disease
Germar-Michael Pinggera, Yannic Kunz, Felician Lackner, Joahnnes Stäblein
Department of Urology, Medical University Innsbruck, Innnsbruck, Austria

#A-0305

A-0305 Infertile couple: what about the man's sexuality?
L. Amrani, H. Brougui, Mrh. Maiz
Department of Urology, Regional University Military Hospital of Blida, Algeria

#A-0306

A-0306 Peyronie's disease surgery and erectile dysfunction: why this risk and how to prevent it?
L. Amrani, H. Brougui, Mrh. Maiz
Department of Urology, Regional University Military Hospital of Blida, Algeria

#A-0307

A-0307 Peyronie's disease and sexual dysfunction: cause or consequence?
L. Amrani, H. Brougui, Mrh. Maiz
Department of Urology, Regional University Military Hospital of Blida, Algeria

#A-0308

A-0308 Unusual complication of a Peyronie's disease plication, a penile fracture 3 weeks postoperatively: a case report and literature review
L. Amrani, H. Brougui, Mrh. Maiz
Department of Urology, Regional University Military Hospital of Blida, Algeria